6216-47-3

Upstream product

• 4515-24-6 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-β-D-glucopyranosylamine 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 6205-69-2 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-β-D-glucopyranosyl azide 
• 1197342-75-8 Z-Gly-STrt 
• 14131-63-6 D-glucosamine hydrochloride 
• 70749-28-9 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucopyranose 
• 824985-67-3 C₁₂H₁₉NO₈ 
• 16707-70-3 2-(((benzyloxy)carbonyl)amino)ethanethioic S-acid 

Downstream Products

• 6216-46-2 2-acetamido-1-N--2-deoxy-β-D-glycopyranosylamine 
• 198225-23-9 C₅₇H₈₇N₉O₁₈ 
• 198225-21-7 C₅₃H₈₁N₇O₁₆ 
• 198225-24-0 C₅₁H₈₁N₉O₁₅ 
• 198225-20-6 [(2-{(2-Benzylamino-acetyl)-[((2R,3R,4R,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-3-acetylamino-tetrahydro-pyran-2-ylcarbamoyl)-methyl]-amino}-acetyl)-isobutyl-amino]-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

First Synthesis of N-Linked-Glycopeptoid as New Glycopeptidomimetics

The first N-linked glycopeptoid containing N-acetylglucosaminide (D-GlcNAc) was synthesized using the oligo(N-substituted glycines) (NSGs) approach.The strategy presented herein offers the advantage of a convergent synthesis.

Rapid formation of N-glycopeptides via Cu(II)-promoted glycosylative ligation

Herein is described the chemoselective Cu(II)-HOBt promoted chemical ligation of glycosylamines and peptide thioacids to give N-glycosylated peptides. The method is distinguished from other chemical approaches to peptide N-glycosylation in that (1) it can be employed in the presence of unprotected N-terminal and Lys side chain amines; (2) it is remarkably fast, going to completion in under 30 min; and (3) it produces glycopeptides without attendant aspartimide formation.

New reactions of selenocarboxylates

(Chemical Equation Presented) By treatment with Woollins' reagent in toluene solution, carboxylic acids are converted to selenocarboxylic acids. The latter react in situ to provide new products of acid- or base-promoted substitution, addition, and amidation.

Synthesis and biological activity of some 1-N-substituted 2-acetamido-2-deoxy-beta-D-glycopyranosylamine derivatives and related analogs.

Several 1-N-substituted derivative [haloacetyl-, glycyl-, (dimethyl)amino-acetyl-, azidoacetyl-, trifluoroacetyl-, and trifluoromethylsulfonyl-] of 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-beta-D-glucopyranosylamine (1) were synthesized as potential metabolic inhibitors of cellular-membrane glycoconjugates. Several fully acetylated derivatives were found to inhibit growth of mouse mammary adenocarcinoma TA3, leukemia L1210, or leukemia P-288 cells at 1-0.01 mM concentration in vitro. Some of these derivatives were less active after O-deacetylation. Analogs of 1 in which NH2-1 was replaced by OH- or OAc-1 were also active on the same cell systems. The growth-inhibitory activity was correlated with inhibition of the incorporation of 2-amino-deoxy-D-glucose and L-leucine into a macromolecular fraction.