6217-61-4

Usage

Uses

Used in Pharmaceutical Research:
(5-methyl)dithiouracil is used as a precursor in the development of antithyroid drugs for its capacity to inhibit the production of thyroid hormones, offering a potential treatment for hyperthyroidism.
Used in Antioxidant and Anti-inflammatory Therapies:
(5-methyl)dithiouracil is utilized in research for its antioxidant and anti-inflammatory properties, which may contribute to the development of new therapeutic agents for various conditions where oxidative stress and inflammation are implicated.
Used in Drug Development:
(5-methyl)dithiouracil is employed as a compound of interest in drug development, with ongoing studies aimed at understanding its potential uses and mechanisms of action to fully harness its therapeutic potential.

InChI:InChI=1/C5H6N2S2/c1-3-2-6-5(9)7-4(3)8/h2H,1H3,(H2,6,7,8,9)

Upstream product

• 65-71-4 thymin 
• 636-26-0 5-methyl-2-thiouracil 

Downstream Products

• 7390-56-9 4-amino-5-methyl-1H-pyrimidine-2-thione 
• 83991-19-9 (4-amino-5-methyl-pyrimidin-2-ylmercapto)-acetic acid 
• 554-01-8 5-methylcytosin 

Relevant academic research and scientific papers

A THIONATION PROCESS AND A THIONATING AGENT

A process for transforming a group >C=O (I) in a compound into a group >C=S (II) or into a tautomeric form of group (II) in a reaction giving a thionated reaction product, by use of crystalline P2S5·2 C5H5N as a thionating agent. A thionating agent which is crystalline P2S5·2 C5H5N

A thionation process and a thionating agent

A process for transforming a group >C=O (I) in a compound into a group >C=S (II) or into a tautomeric form of group (II) in a reaction giving a thionated reaction product, by use of crystalline P2S5·2 C5H5N as a thionating agent. A thionating agent which is crystalline P2S5·2 C5H5N.

Thionations using a P4S10-pyridine complex in solvents such as acetonitrile and dimethyl sulfone

Tetraphosphorus decasulfide (P4S10) in pyridine has been used as a thionating agent for a long period of time. The moisture-sensitive reagent has now been isolated in crystalline form, and the detailed structure has been determined by X-ray crystallography. The thionating power of this storable reagent has been studied and transferred to solvents such as acetonitrile in which it has proven to be synthetically useful and exceptionally selective. Its properties have been compared with the so-called Lawesson reagent (LR). Particularly interesting are the results from thionations at relatively high temperatures (165 °C) in dimethyl sulfone as solvent. Under these conditions, for instance, acridone and 3-acetylindole could quickly be transformed to the corresponding thionated derivatives. Glycylglycine similarly gave piperazinedithione. At these temperatures, LR is inefficient due to rapid decomposition. The thionated products are generally cleaner and more easy to obtain because in the crystalline reagent, impurities which invariably are present in the conventional reagents, P4S 10 in pyridine or LR, have been removed. 2011 American Chemical Society.

A Rapid and Efficient Synthesis of Sulfur Analogues of Pyrimidine Bases

An improved procedure for thionation of some natural pyrimidine bases with tetraphosphorus decasulfide/sodium hydrogen carbonate is reported.Some substituted uracils and 2-thiouracils were converted into a series of analogues in which the oxygen at position 4 was replaced by sulfur atom.The advantage of this method of thionation over the older procedures is based on the tetraphosphorus decasulfide/sodium hydrogen carbonate mixture giving rise to excellent yields and simplified isolation of the desired pure products.