62176-08-3Relevant academic research and scientific papers
4-Nitroperhydropyrido[1,2-a][1,4]diazepines
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, (2008/06/13)
Compounds of the formula v,2/12 Wherein R1 is H, lower-alkyl, hydroxyalkyl, phenyl, aralkyl, or --(CH2) n --X wherein n is 0-4 and X is --COO-lower-alkyl, C N or --COOH and R2 is H, lower-alkyl or aralkyl, produced by condensing a diamine of the formula SPC1 With a nitro compound of the formula R1 --CH2 --NO2 in the presence of formalin or paraformaldehyde, or with the R1 -- C(CH2 OH)2 NO2 reaction product of the above nitro compound and formalin or paraformaldehyde, or with formalin or paraformaldehyde followed by reaction with the above nitro compound, and their acid addition salts, possess antimicrobial activity against both gram-positive and gram-negative bacteria and also against dermatophytes, yeasts and other fungi.
