62183-31-7Relevant academic research and scientific papers
Catalytic asymmetric epoxidation
-
, (2008/06/13)
The present invention provides a variety of methods that are based on stereoselective epoxidation of an olefin by an epoxidizing agent derived from a reaction between an oxidizing agent and a chiral ketone. For example, present invention provides methods for producing an epoxide from an olefin, for increasing a relative concentration of at least one stereoisomer of an olefin, and for stereoselectively producing an α-acyloxy carbonyl compound. Preferably, the chiral ketone is of the formula: or a derivative thereof which is capable of converting to the chiral ketone of Formula I under the reaction conditions, where a, b, n, X, R1, R2, R3, R4, R5and R6are those defined herein.
Catalytic asymmetric epoxidation
-
, (2008/06/13)
The present invention provides a variety of methods that are based on stereoselective epoxidation of an olefin by an epoxidizing agent derived from a reaction between an oxidizing agent and a chiral ketone. For example, present invention provides methods for producing an epoxide from an olefin, for increasing a relative concentration of at least one stereoisomer of an olefin, and for stereoselectively producing an α-acyloxy carbonyl compound. Preferably, the chiral ketone is of the formula: or a derivative thereof which is capable of converting to the chiral ketone of Formula I under the reaction conditions, where a, b, n, X, R1, R2, R3, R4, R5 and R6 are those defined herein.
Epoxidation of Enol Silyl Ethers, Phosphates, Esters, and Lactones by Dimethyldioxirane
Adam, Waldemar,Hadjiarapoglou, Lazaros,Jaeger, Volker,Klicic, Jasna,Seidel, Bernhard,Wang, Xiaoheng
, p. 2361 - 2368 (2007/10/02)
The epoxides 2a-u (Table 1) of the enol silyl ethers 1a, b, enol phosphates 1c-k, and enol esters and lactones 1l-u were prepared in excellent yields by epoxidation with isolated dimethyldioxirane (4) (as acetone solution).These labile epoxides (stable be
EPOXIDATION OF γ-METHYLENE-γ-BUTYROLACTONES BY DIMETHYLDIOXIRANE
Adam, Waldemar,Hadjiarapoglou, Lazaros,Jaeger, Volker,Seidel, Bernhard
, p. 4223 - 4226 (2007/10/02)
Dimethyldioxirane (as acetone solution) converts γ-methylene-γ-butyrolactones and other enol lactones and esters to the corresponding epoxides in excellent yields.
