6220-50-4

Basic information

• Product Name: 2(1H)-Pyrimidinone, 4-amino-6-methyl- (9CI)
• Synonyms: 2(1H)-Pyrimidinone, 4-amino-6-methyl- (9CI);4-Amino-6-methyl-2(1H)-pyrimidinone;6-Methylcytosine
• CAS NO: 6220-50-4
• Molecular Formula: C₅H₇N₃O
• Molecular Weight: 125.12858
• Product Categories: PYRIMIDINE
• Mol File: 6220-50-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.44g/cm³
• Refractive Index: 1.651
• CAS DataBase Reference: 2(1H)-Pyrimidinone, 4-amino-6-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyrimidinone, 4-amino-6-methyl- (9CI)(6220-50-4)
• EPA Substance Registry System: 2(1H)-Pyrimidinone, 4-amino-6-methyl- (9CI)(6220-50-4)

Safety Data

• Hazardous Substances Data: 6220-50-4(Hazardous Substances Data)

Usage

General Description

2(1H)-Pyrimidinone, 4-amino-6-methyl- (9CI) is a chemical compound with the molecular formula C5H6N2O. It is a derivative of pyrimidine and is used in various pharmaceutical applications due to its structural and functional properties. 2(1H)-Pyrimidinone, 4-amino-6-methyl- (9CI) has been studied for its potential antiviral and anticancer activity, and it is also used in the synthesis of various medicinal products. Additionally, 2(1H)-Pyrimidinone, 4-amino-6-methyl- (9CI) may have applications in the development of new drugs and therapies for a range of medical conditions.

InChI:InChI=1/C5H7N3O/c1-3-2-4(6)8-5(9)7-3/h2H,1H3,(H3,6,7,8,9)

Upstream product

• 16710-12-6 6-methyl-cytidine 

Downstream Products

• 626-48-2 6-Methyluracil 
• 134419-41-3 1-Acetyl-4-amino-5-hydroxy-1H-imidazol-2(5H)-one 

Relevant articles and documents

Reactions of pyrimidine nucleosides with aqueous alkalies: kinetics and mechanisms.

Kinetics for the reactions of various cytosine and uracil nucleosides and their alkyl derivatives with aqueous sodium hydroxide have been studied by liquid chromatography. Blocking of the glycosyl hydroxyl groups with alkyl groups and changes in the glycon moiety configuration have been observed to exert only moderate effects on the rate of deamination of cytosine nucleosides. Methylation of the 4-amino group retards deamination considerably, while a methyl substituent at C5 is rate accelerating and at C6 only moderately rate retarding. These findings have been accounted for by a mechanism involving a rate limiting bimolecular displacement of the 4-amino group by a hydroxide ion. Analogous comparisons with uracil nucleosides suggest that the decomposition of uridine is initiated by an intermolecular attack of hydroxide ion on the C5 atom of the base moiety. In contrast, beta-D-arabino- and beta-D-lyxo-furanosyl derivatives appear to be cleaved via an intramolecular nucleophilic attack of the ionized 2'-hydroxyl group.