62205-56-5

Upstream product

• 4048-33-3 6-amino-1-hexanol 
• 17996-12-2 N-benzyloxycarbonyl-6-amino-1-hexanol 
• 10378-06-0 2-methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-α-D-glucopyranoso)[1,2-d]-2-oxazoline 
• 3006-60-8 Acetic acid (2R,3R,4R,5S,6R)-2,5-diacetoxy-6-acetoxymethyl-3-acetylamino-tetrahydro-pyran-4-yl ester 
• 3068-34-6 Acetic acid (2R,3S,4R,5R,6R)-3-acetoxy-2-acetoxymethyl-5-acetylamino-6-chloro-tetrahydro-pyran-4-yl ester 

Downstream Products

• 62205-57-6 6-[(N-Benzyloxycarbonyl)amino]hexyl 2-N-acetamido-2-deoxy-β-D-glucopyranoside 
• 74666-19-6 6-<(Benzyloxycarbonyl)amino>hexyl O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranoside 
• 74653-39-7 Acetic acid (2R,3S,4S,5R,6R)-3,5-diacetoxy-2-acetoxymethyl-6-[(2R,3S,4R,5R,6R)-5-acetylamino-4-benzyloxy-6-(6-benzyloxycarbonylamino-hexyloxy)-3-hydroxy-tetrahydro-pyran-2-ylmethoxy]-tetrahydro-pyran-4-yl ester 
• 74653-36-4 6-(benzyloxycarbonylamino)-1-hexyl 2-acetamido-2-deoxy-4,6-O-isopropylidene-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-β-D-glucopyranoside 
• 74666-20-9 6-<(Benzyloxycarbonyl)amino>hexyl O-(β-D-galactopyranosyl)-(1->4)-2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranoside 
• 74653-35-3 6-<(Benzyloxycarbonyl)amino>hexyl 2-acetamido-3,4,6-tri-O-benzyl-2-deoxy-β-D-glucopyranoside 
• 74653-40-0 6-(benzyloxycarbonylamino)-1-hexyl 2-acetamido-3-O-benzyl-2-deoxy-6-O-β-D-galactopyranosyl-β-D-glucopyranoside 
• 74653-33-1 6-<(Benzyloxycarbonyl)amino>hexyl 2-acetamido-3,6-di-O-benzyl-2-deoxy-β-D-glucopyranoside 
• 74653-37-5 {6-[(4aR,6R,7R,8R,8aS)-7-Acetylamino-2,2-dimethyl-8-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy]-hexyl}-carbamic acid benzyl ester 
• 74653-34-2 [6-((2R,3R,4R,5S,6R)-3-Acetylamino-4,5-bis-benzyloxy-6-hydroxymethyl-tetrahydro-pyran-2-yloxy)-hexyl]-carbamic acid benzyl ester 
• 74653-38-6 6-(benzyloxycarbonylamino)-1-hexyl 2-acetamido-2-deoxy-3-O-β-D-galactopyranosyl-β-D-glucopyranoside 
• 74653-32-0 6-(benzyloxycarbonylamino)-1-hexyl 2-acetamido-6-O-acetyl-3-O-benzyl-2-deoxy-β-D-glucopyranoside 
• 74653-30-8 [6-((4aR,6R,7R,8R,8aS)-7-Acetylamino-8-benzyloxy-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxy)-hexyl]-carbamic acid benzyl ester 
• 74653-31-9 6-(benzyloxycarbonylamino)-1-hexyl 2-acetamido-3-O-benzyl-2-deoxy-β-D-glucopyranoside 

Relevant academic research and scientific papers

TRIPTOLIDE CONJUGATES AND USES THEREOF

This disclosure provides triptolide-conjugates, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, as well methods of using such compounds in the treatment of conditions/diseases, such as those relating to cancer, immunomodulation and/or inflammation.

Synthesis and antibody-binding studies of a series of parasite fuco-oligosaccharides

Complex multifucosylated oligosaccharides are structural elements of glycoprotein and glycolipid subsets of larval, egg, and adult stages of Schistosoma, the parasitic worms that cause schistosomiasis, a serious disease affecting more than 200 million peo

Chemo-enzymatic synthesis of glycopolymers and sequential glycopeptides bearing lactosamine and sialyl Lewisx unit pendant chains

A variety of glycoconjugates bearing either N-acetyllactosamine or sialyl Lewisx units have been synthesised in a chemo-enzymatic way. This includes the synthesis of glycopolymer copolymerised with acrylamide and whose glucosamine unit was substituted with different kinds of side-chain. Glycopeptides with different spacer-arm glucosamine units have also been prepared and polymerised. The sugar chain was then elongated using glycosyl transferases to afford the novel sequential glycopeptides. In these cases, the polymeric sugar cluster effect led to enzymatic glycosylation with high efficiency. Nevertheless, some differences have been noticed depending on the reaction conditions used for each substrate.

Large scale synthesis of linker-modified sialyl Lewis(X), Lewis(X) and N-acetyllactosamine

The synthesis of sialyl-Lewis(X) (1b), Lewis(X) (2) and N- acetyllactosamine (3), each being attached to the 1β-O-(6-amino)hexyl handle, were scaled up to gram amounts to obtain sufficient material for thorough pharmaceutical evaluations and for derivatisations aiming at more potent selectin antagonists. The disaccharide 3 was synthesised from inexpensive lactose to provide a versatile building block, either to be used for alternative approaches to the Lewis type oligosaccharides, or to prepare polyvalent LacNAc templates to be further elaborated by glycosyltransferase reactions. All syntheses were directed to reasonable large scale procedures, especially by minimising the number of steps and the use of heavy metal salts in glycosylations.

Process for the specific synthesis of β-glycosidically linked N-acetylpyranoside derivatives

A process for the stereospecific synthesis of β-glycosidically linked N-acetylglucosamine derivatives is provided, wherein a protected α-(N-acetyl-2-amino-2-deoxy)-β-pyranosyl halide is coupled to a glycosyl acceptor using zinc chloride and a 4,4'-dialkox

SYNTHESIS OF 6-AMINO-1-HEXYL 2-ACETAMIDO-2-DEOXY-3-, -4-, AND -6-O-β-D-GALACTOPYRANOSYL-β-D-GLUCOPYRANOSIDES

6-Aminohexyl glycosides of β-D-Gal β-D-GlcNAc disaccharides having β-(13)-, β-(14)-, and β-(16)-linkages were prepared. 6-(Benzyloxycarbonylamino)-1-hexanol was glycosylated with 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranosyl chlor