62206-13-7

Usage

Uses

Used in Drug Discovery and Development:
1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE is used as a potential lead compound for drug discovery and development due to its unique chemical structure and pharmacological properties. Its dihydroisoquinoline framework and functional groups may contribute to its interaction with biological targets, making it a promising candidate for further research and optimization in the development of new therapeutic agents.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE is utilized as a starting point for the design and synthesis of novel compounds with potential therapeutic applications. Its chemical features can be modified and optimized to enhance its pharmacological properties, such as potency, selectivity, and bioavailability.
Used in Pharmacology Research:
1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE serves as a valuable tool in pharmacology research, where it can be employed to investigate the mechanisms of action, pharmacokinetics, and pharmacodynamics of potential drug candidates. Its unique structure allows researchers to explore its interactions with various biological targets and pathways, contributing to a better understanding of its therapeutic potential and limitations.

InChI:InChI=1/C17H15ClN2O4/c1-23-15-7-10-5-6-19-17(12(10)9-16(15)24-2)13-8-11(18)3-4-14(13)20(21)22/h3-4,7-9H,5-6H2,1-2H3

Upstream product

• 301174-19-6 5-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-nitrobenzamide 
• 41994-44-9 5-chloro-2-nitrobenzoyl chloride 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 

Downstream Products

• 62206-12-6 4-chloro-2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)aniline 
• 62206-16-0 6,7-dimethoxy-1-(5-chloro-2-aminophenyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant academic research and scientific papers

Synthesis and?antitumor activity of?cis-dichloroplatinum(II) complexes of?1-(2-aminophenyl)-1,2,3,4-tetrahydroisoquinolines

Fifteen cis-dichloroplatinum complexes (5a-5o) were synthesized by treatment of 1-(2-aminophenyl)-1,2,3,4-THIQs (4a-4o) with K2PtCl4. The antitumor activity of these compounds was examined against four different human tumor cell lines. Their structure-activity relationships for antitumor activity are reported. All of these compounds exhibited activity against MCF-7 cell line and showed good activity against WiDr cell line except 5c and 5f. On the other hand, compounds 5j and 5o are more active than the other compounds against Hepa59T/VGH cell line. The electron-donating group at the 6-position of isoquinoline ring seems to decrease the antitumor activity and the chloro substituent at the C-4 position of the aniline ring shown the highest potency. The "trans influence" dominates the control of the stability of [1-(2-aminophenyl)-1,2,3,4-THIQ]dichloroplatinums(II).

A novel synthesis of 5,6-dihydroindazolo[3,2-a]isoquinolines and their relative compounds via tin(II) chloride dihydrate as reducing agent

A series of 1-(2-nitrophenyl)-3,4-dihydroisoquinolines were reduced under very mild reaction conditions in the presence of Tin(II) chloride dihydrate (SnCl2·2H2O) to give 5,6-dihydroindazolo[3,2-a] isoquinolines 4a-h. A mechanism for

Synthesis of indazole-N-oxides via the 1,7-electrocyclization of azomethine ylides

The first examples of the 1,7-electrocyclization of azomethine ylides onto a nitro group, to give benz-1,2,6-oxadiazepine intermediates are reported. Subsequent ring contraction results in the formation of indazole-N-oxides. Graphical Abstract