62212-14-0

Usage

Uses

Used in Pharmaceutical Industry:
N-MALEONYL-(S)-ALANINE is used as a key intermediate in the synthesis of maleimide-based pharmaceutical compounds for various therapeutic applications. Its unique structure allows for the development of new drugs with improved efficacy and selectivity.
Used in Chemical Synthesis:
In the field of chemical synthesis, N-MALEONYL-(S)-ALANINE is utilized as a versatile building block for the creation of a wide range of maleimide derivatives. These derivatives can be further used in the development of new materials, catalysts, and other specialty chemicals.
Used in Research and Development:
N-MALEONYL-(S)-ALANINE is employed as a research tool in academic and industrial laboratories, where it is used to explore the properties and potential applications of maleimide chemistry. Its unique structure makes it an attractive candidate for studying the reactivity and selectivity of maleimide-based reactions.

InChI:InChI=1/C7H7NO4/c1-4(7(11)12)8-5(9)2-3-6(8)10/h2-4H,1H3,(H,11,12)

Upstream product

• 108-31-6 maleic anhydride 
• 302-72-7 rac-Ala-OH 

Downstream Products

• 76-05-1 trifluoroacetic acid 
• 149056-08-6 DL-2,5-Dioxo-α-methyl-3-pyrroline-1-acet-p-anisidide 

Relevant academic research and scientific papers

Synthesis and study of modified polyvinyl alcohol containing amino acid moieties as anticancer agent

A series of new phthalimides compounds[3-7]a-i were synthesized from reaction of Malic anhydride, phthalic anhydride, nitro phthalic anhydride, 2-phenyl-4H-benzo[d][1,3]oxazin-4-one, 2-(4-nitrophenyl)-4H-benzo[d][1,3]oxazin-4-one with different amino acids as glycine, alanine, valine, leucine, isoleucine, serine, threonine, tyrosine and Phenyl alanine [1]a-i under fusion conditions. Compounds [3-7]a-i react with SOCl2 in the presence of benzene to produce compounds [8-12]a-i. Chemical modification of Poly(vinyl alcohol)were obtained by reaction of PVA with compounds [8-12]a-i using the dimethyl formamide to give compounds [13-17]a-i. The structure of the synthesized compounds was characterized by their analytical and spectral data as, IR spectra, 1H, 13C-NMR, Elemental analysis (CHN), UV-Vis Spectroscopy, Scanning electron microscopy (SEM), Antibacterial activity were screened via two kinds of bacteria. Also, anticancer activity were examined for most of the modified polyvinyl alcohol.

Active energy ray curable composition comprised of a maleimide derivative and a method for curing the said curable composition

Objects of the present invention are the provision of an active energy ray curable composition which can be cured in the absence of a photoinitiator, and which can also be cured at practical light intensities and irradiating energy, and a method for curing the said curable composition; in which the composition comprises a maleimide derivative represented by formula (1): whereinm and n each represent an integer of 1 to 5, and the total of m and n is 6 or smaller,R11 and R12 each represent a linking group selected from the group consisting of {circle around (1)} an alkylene group, {circle around (2)} an alicyclic group, {circle around (3)} an arylalkylene group, and {circle around (4)} a cycloalkylalkyene group,G1 and G2 each represent an ester linkage selected from the group consisting of —COO— and —OCO—,R2 represents a linking chain having an average molecular weight of 100 to 100,000 selected from the group consisting of (A) a (poly)ether linking chain and (B) a (poly)ester linking chain, in which at least one organic group selected from the group consisting of {circle around (1)} a straight chain alkylene group, {circle around (2)} a branched alkylene group, {circle around (3)} an alkylene group having a hydroxyl group, {circle around (4)} an alicyclic group, {circle around (5)} an aryl group, and {circle around (6)} an arylalkylene group is connected via at least one linkage selected from the group consisting of (a) an ether linkage and (b) an ester linkage.

Microwave-induced One-pot Synthesis of N-carboxyalkyl Maleimides and Phthalimides

Maleic and phthalic anhydride condenses with amino acids and alkylamines under microwave irradiation to afford N-substituted maleimides and phthalimides in excellent yields.