62214-19-1

Basic information

• Product Name: (6-HYDROXY-4-METHYL-2-THIOXO-1,2-DIHYDRO-PYRIMIDIN-5-YL)-ACETIC ACID
• Synonyms: (6-HYDROXY-4-METHYL-2-THIOXO-1,2-DIHYDRO-PYRIMIDIN-5-YL)-ACETIC ACID;(2-Mercapto-4-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)acetic acid;2-(4-hydroxy-2-mercapto-6-methylpyrimidin-5-yl)acetic acid
• CAS NO: 62214-19-1
• Molecular Formula: C₇H₈N₂O₃S
• Molecular Weight: 200.22
• Mol File: 62214-19-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 295 °C(Solv: acetic acid (64-19-7))
• Appearance: /
• Density: 1.52±0.1 g/cm3(Predicted)
• PKA: 3.82±0.10(Predicted)
• CAS DataBase Reference: (6-HYDROXY-4-METHYL-2-THIOXO-1,2-DIHYDRO-PYRIMIDIN-5-YL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (6-HYDROXY-4-METHYL-2-THIOXO-1,2-DIHYDRO-PYRIMIDIN-5-YL)-ACETIC ACID(62214-19-1)
• EPA Substance Registry System: (6-HYDROXY-4-METHYL-2-THIOXO-1,2-DIHYDRO-PYRIMIDIN-5-YL)-ACETIC ACID(62214-19-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 62214-19-1(Hazardous Substances Data)

Usage

General Description

(6-Hydroxy-4-methyl-2-thioxo-1,2-dihydro-pyrimidin-5-yl)-acetic acid is a chemical compound with potential pharmacological properties. It contains a pyrimidine ring and a thioxo group, and it also has a hydroxy and a methyl substituent. (6-HYDROXY-4-METHYL-2-THIOXO-1,2-DIHYDRO-PYRIMIDIN-5-YL)-ACETIC ACID may have potential applications in pharmaceutical research, particularly in the areas of drug development and medicinal chemistry. Further studies may be necessary to explore its potential therapeutic uses and to determine its safety and efficacy for potential medical applications.

Upstream product

• 1115-30-6 diethyl acetylsuccinate 
• 17356-08-0 thiourea 
• 10420-33-4 dimethyl 2-acetylsuccinate 

Downstream Products

• 162498-46-6 (4-chloro-6-methyl-pyrimidin-5-yl)-acetic acid methyl ester 
• 1265396-65-3 methyl 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoate 
• 1265396-71-1 2-(4-methyl-2-(3-phenylpiperidin-1-yl)-6-p-tolylpyrimidin-5-yl)pentanoic acid 
• 1265396-77-7 methyl 2-(2-[(S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate 
• 1265396-83-5 2-(2-((S)-3-(dimethylamino)pyrrolidin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoic acid 
• 1265396-89-1 methyl 2-(2-(4-benzamidopiperidin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate 
• 1265396-94-8 2-(2-(4-benzamidopiperidin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoic acid 
• 1265396-99-3 methyl 2-(2-(4-ethyl-1,4-diazepan-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate 
• 1265397-04-3 2-(2-(4-ethyl-1,4-diazepan-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoic acid 
• 1265397-10-1 methyl 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoate 
• 1265397-16-7 2-(2-(indolin-1-yl)-4-methyl-6-p-tolylpyrimidin-5-yl)pentanoic acid 
• 1265393-19-8 methyl 2-(2-chloro-4-methyl-6-phenylpyrimidin-5-yl)acetate 
• 1265400-31-4 methyl 4-methoxy-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)butanoate 
• 1265400-41-6 methyl 6,6,6-trifluoro-2-(4-methyl-2-(piperidin-1-yl)-6-p-tolylpyrimidin-5-yl)hexanoate 

Relevant articles and documents

SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1

Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.

Dimethyl acetylsuccinate as a versatile synthon in heterocyclic chemistry - A facile synthesis of heterocyclic acetic acid derivatives

The preparation of novel acetic acid derivatives of pyrazole 3a,b and pyrimidine 2a-e is achieved by condensation of dimethyl acetylsuccinate (1) with appropriate reaction partners. Also triethyl 1,1,2-ethanetricarboxylate (6) is a valuable starting material, which is demonstrated by the synthesis of previously unknown pyrimidin-5-yl acetates. Wiley-VCH Verlag GmbH, 2000.