62224-17-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Thiophenecarboxylic acid, 4-bromo-, ethyl ester is used as an intermediate or starting material in organic synthesis for the development of new drugs. Its unique properties and reactivity make it a valuable component in the creation of pharmaceutical compounds.
Used in Agrochemical Production:
2-Thiophenecarboxylic acid, 4-bromo-, ethyl ester is also used in the production of agrochemicals, where its reactive nature allows for the development of new and effective products for agricultural applications.
Used in Dye Manufacturing:
2-Thiophenecarboxylic acid, 4-bromo-, ethyl ester is utilized in the manufacturing of dyes, taking advantage of its chemical properties to create a variety of colorants for different industries.
Used in Specialty Chemicals:
2-Thiophenecarboxylic acid, 4-bromo-, ethyl ester finds application in the production of specialty chemicals, where its unique characteristics contribute to the development of innovative and specialized products for various industries.

Upstream product

• 6324-10-3 4,5-Dibromo-thiophene-2-carboxylic acid 
• 2810-04-0 Ethyl thiophene-2-carboxylate 

Downstream Products

• 16694-18-1 4-bromo-thiophene-2-carboxylic acid 
• 1232068-99-3 Ethyl 4-(3-chlorophenyl)thiophene-2-carboxylate 
• 1232069-02-1 Ethyl 5-bromo-4-(3-chlorophenyl)thiophene-2-carboxylate 
• 1232069-05-4 5-Bromo-4-(3-chlorophenyl)thiophene-2-carboxylic acid 
• 1232069-08-7 1-{[5-Bromo-4-(3-chlorophenyl)thiophen-2-yl]carbonyl}imidazolidin-4-one 
• 1232068-54-0 1-{[5-(3-Chloro-5-fluorophenyl)-4-(3-chlorophenyl)thiophen-2-yl]carbonyl}imidazolidin-4-one 
• 1232068-57-3 5-{3-(3-Chlorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-2-fluorobenzenecarbonitrile 

Relevant academic research and scientific papers

Direct bromination of ethyl 5-alkylthiophene-2-carboxylates

Approaches to brominated thiophene-2-carboxylic acids by electrophilic bromination of the corresponding acids and esters were compared and investigated. A synthetic route was developed involving direct bromination of ethyl 5-alkylthiophene-2-carboxylates followed by saponification of the resulting ethyl 5-alkyl-4-bromothiophene-2-carboxylates. The key bromination step is selective in dichloromethane solution at 0-5 °C and furnishes the corresponding ethyl 5-alkyl-4-bromothiophene-2-carboxylates in excellent yields. No migration or isomerization of the alkyl substituents was observed. Georg Thieme Verlag Stuttgart New York.

Compounds and compositons for treating C1s-mediated diseases and conditions

Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4, X, Y and Z are defined in the specification.

Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors

The present invention is directed to compounds of Formula I: wherein X is O, S or NR7and R1-R7, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.