62224-25-3

Upstream product

• 2810-04-0 Ethyl thiophene-2-carboxylate 

Downstream Products

• 1232068-93-7 Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate 
• 1232069-14-5 Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)thiophene-2-carboxylate 
• 1232069-17-8 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid 
• 1232068-44-8 3-{2-(3-Chloro-5-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile 
• 1232068-69-7 3-{3-(3-Chloro-4-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-2-yl}-5-fluorobenzenecarbonitrile 
• 1232069-37-2 ethyl 4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylate 
• 1256373-91-7 4-(3-chloro-4-fluorophenyl)-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylic acid 
• 1232068-87-9 Ethyl 4-bromo-5-(3-chloro-5-fluorophenyl)thiophene-2-carboxylate 
• 1232069-34-9 ethyl 4-bromo-5-(3-cyano-5-fluorophenyl)thiophene-2-carboxylate 
• 1395084-14-6 ethyl 4,5-bis(4-chloro-2-isopropylphenyl)thiophene-2-carboxylate 
• 1395083-73-4 4,5-bis(4-chloro-2-isopropylphenyl)thiophene-2-carboxylic acid 

Relevant academic research and scientific papers

DIPHENYL SUBSTITUTED THIOPHENE-2-AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIMICROBIAL

Compounds or pharmaceutical acceptable salts thereof of Formula (I), in which RM have the meaning described herein and pharmaceutical compositions thereof useful as antimicrobial and/or adjuvant:

ANTIMICROBIAL/ADJUVANT COMPOUNDS AND METHODS

Among other things, in general, antimicrobial and/or adjuvant compounds are provided according to Formula la: (Ia) in which E and R1-11 have the meanings described herein; and prodrugs and pharmaceutically acceptable salts thereof. Other formulae and methods of use are also provided.

SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF

The present invention relates to novel substituted (thiophenyl-carbonyl)imidazolidinones, methods for their production, their use for the treatment and/or prevention of diseases, as well as their use for the production of medicaments for the treatment and/or prophylaxis of diseases, especially retroviral diseases, in humans and/or animals.

Direct bromination of ethyl 5-alkylthiophene-2-carboxylates

Approaches to brominated thiophene-2-carboxylic acids by electrophilic bromination of the corresponding acids and esters were compared and investigated. A synthetic route was developed involving direct bromination of ethyl 5-alkylthiophene-2-carboxylates followed by saponification of the resulting ethyl 5-alkyl-4-bromothiophene-2-carboxylates. The key bromination step is selective in dichloromethane solution at 0-5 °C and furnishes the corresponding ethyl 5-alkyl-4-bromothiophene-2-carboxylates in excellent yields. No migration or isomerization of the alkyl substituents was observed. Georg Thieme Verlag Stuttgart New York.

DESIGN AND SYNTHESIS OF NOVEL ANTIMICROBIALS

The synthesis and activity of novel LpxA inhibitors is described, these inhibitors present antibacterial activity. The compounds were designed based on a receptor model developed using the crystal structure of LpxA and are arranged to have a favorable bin

Halogenation Using Quaternary Ammonium Polyhalides. XXXI. Halogenation of Thiophene Derivatives with Benzyltrimethylammonium Polyhalides

The reactions of thiophene derivatives with benzyltrimethylammonium tetrachloroiodate, benzyltrimethylammonium tribromide, and benzyltrimethylammonium dichloroiodate in acetic acid or in acetic acid-zinc chloride under mild conditions gave chloro-, bromo-, and iodo-substituted thiophene derivatives, respectively, in satifactory yields.