62227-09-2Relevant articles and documents
Coupling of N-trifluoroacetyl amino acids under 'neutral' conditions.
Benouargha, Amina,Verducci, Jean,Jacquier, Robert
, p. 824 - 828 (2007/10/02)
The possibility of using the trifluoroacetyl group as a base-labile N-protection in peptide synthesis is discussed.Under normal coupling conditions, a very high level of racemization is observed.However, when 'neutral' coupling conditions (by silylation of amino acids or peptides) were used, the coupling racemization decreased as much as 1-2percent. - Key words: peptide coupling; N-protection; N-trifluoroacetyl amino acid; racemization, silylated amino acid