622336-82-7

Upstream product

• 71400-63-0 N-tert-butyloxycarbonyl-3-iodo-L-tyrosine 
• 691394-91-9 methyl (S)-3-(4-(benzyloxy)-3-iodophenyl)-2-((tert-butoxycarbonyl)amino)propanoate 
• 119336-08-2 methyl (S)-2-((tert-butoxycarbonyl)amino)-3-(4-hydroxy-3-iodophenyl)propanoate 
• 113850-71-8 (S )-methyl 2-((tert-butoxycarbonyl)amino)-3-(3-iodo-4-methoxyphenyl)propanoate 
• 74-88-4 methyl iodide 
• 70-78-0 3-Iodo-L-tyrosine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 579469-92-4 [1-hydroxymethyl-2-(3-iodo-4-methoxy-phenyl)-ethyl]-carbamic acid tert-butyl ester 
• 911675-87-1 C₁₉H₂₃IN₂O₇ 
• 2387-23-7 1,3-Dicyclohexylurea 
• 911675-83-7 N-Boc-3-iodo-Tyr(Me)-NH-(Bn)Ala-OMe 
• 1417697-55-2 H-Tyr(3-BPin,Me)-Leu-Leu-NH₂ 
• 1417697-57-4 H-Tyr[3-B(OH)2,Me]-Leu-Leu-NH₂ 
• 579469-85-5 (2S,3S)-2-{(S)-3-[5'-((S)-2-Benzyloxycarbonylamino-2-methoxycarbonyl-ethyl)-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionylamino}-3-methyl-pentanoic acid benzyl ester 
• 579469-88-8 (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-3-[5'-((S)-2-tert-butoxycarbonylamino-3-methoxymethoxy-propyl)-5-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-propionic acid methyl ester 
• 579469-90-2 (S)-3-[5'-[(S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-2-methoxycarbonyl-ethyl]-3'-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-2-tert-butoxycarbonylamino-propionic acid 
• 579469-89-9 (S)-2-((2S,3S)-2-Benzyloxycarbonylamino-3-methyl-pentanoylamino)-3-[5'-((S)-2-tert-butoxycarbonylamino-3-hydroxy-propyl)-5-(tert-butyl-dimethyl-silanyloxy)-6,2'-dimethoxy-biphenyl-3-yl]-propionic acid methyl ester 

Relevant academic research and scientific papers

Concise Total Synthesis of Herqulines B and C

A simple total synthesis of herqulines B and C is reported, modeled on the reductive biosynthesis reported previously by other researchers. Commencing from tyrosine, these alkaloids were fashioned through a dimerization, macrocyclization, and four consecu

Scalable Synthesis of Mycocyclosin

We report herein the scalable total synthesis of the secondary metabolite, mycocyclosin, initially isolated from Mycobacterium tuberculosis. Mycocylosin bears a highly strained 3,3′-dityrosine biaryl system which arises biosynthetically from an intramolec

COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY

The present invention relates to the use of compounds of the following general formula (I): wherein no is 0 or 1, and when no is 1, X = CH2 or X = NCH2C6H5; R1 is OH, or a OR10 group, or a group of formula NH-(CH2)n1-R11; R2 is H, or an alkyl group, or a group of formula (CH2)n2-(CO)n3-NR13R14; R3 is H, or an alkyl group; R4 is H, or Boc, or Z; R5 is H, or Boc, or Z ; R6 is a OR16 group; R7 and R8 are H, or a halogen atom, as modulators of the proteasome activity, in the frame of the preparation of a medicament useful for the prevention or treatment of diseases wherein the proteasome is involved, or the preparation of cosmetic compositions, or of phytosanitary compositions.

Synthesis of the (S,S,S)-diastereomer of the 15-membered biaryl ring system of RP 66453

The synthesis of the 15-membered biaryl ring system constituting an appropriately functionalized AB ring system of RP 66453 is detailed.