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622369-46-4

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  • 3-Quinolinecarbonitrile, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-

    Cas No: 622369-46-4

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622369-46-4 Usage

General Description

4-[(2,4-Dichloro-5-methoxyphenyl)amino]-7-fluoro-6-methoxy-3-quinolinecarbonitrile is a complex organic compound with a variety of potential applications, most notably in the field of pharmacology. This molecule features several notable functional groups, including two methoxy groups, a nitrile group, a fluoro group, and an amino group. These chemical moieties can potentially interact with various biological systems, suggesting that this compound might be used as a medicinal drug or as a biological probe. However, it's worth noting that exact properties such as toxicity, solubility, and bioavailability can vary greatly depending on the specific context and should be evaluated carefully before any practical use. Currently, exact uses and properties of this compound in scientific literature are sparse and hence further research is needed to understand its full potential.

Check Digit Verification of cas no

The CAS Registry Mumber 622369-46-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,2,3,6 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 622369-46:
(8*6)+(7*2)+(6*2)+(5*3)+(4*6)+(3*9)+(2*4)+(1*6)=154
154 % 10 = 4
So 622369-46-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H12Cl2FN3O2/c1-25-16-6-15(11(19)4-12(16)20)24-18-9(7-22)8-23-14-5-13(21)17(26-2)3-10(14)18/h3-6,8H,1-2H3,(H,23,24)

622369-46-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(2,4-dichloro-5-methoxyanilino)-7-fluoro-6-methoxyquinoline-3-carbonitrile

1.2 Other means of identification

Product number -
Other names QC-5180

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:622369-46-4 SDS

622369-46-4Relevant articles and documents

Preparation method of intermediate for leukemia treatment medicines

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Paragraph 0037-0041; 0044-0050; 0051-0057; 0058-0067, (2019/01/23)

The invention belongs to the technical field of chemical medicines, and specifically relates to a preparation method of an intermediate for leukemia treatment medicines. The method comprises the stepsof supporting N-[3-(triethoxysilyl)propyl]-4,5-dihydroi

Process for preparation of 4-amino-3-quinolinecarbonitriles

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Page/Page column 11, (2010/02/10)

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.

7-Alkoxy-4-phenylamino-3-quinolinecarbonitriles as Dual Inhibitors of Src and Abl Kinases

Boschelli, Diane H.,Wang, Yanong D.,Johnson, Steve,Wu, Biqi,Ye, Fei,Barrios Sosa, Ana Carolina,Golas, Jennifer M.,Boschelli, Frank

, p. 1599 - 1601 (2007/10/03)

We previously reported that several 7-alkoxy-4-phenylamino-3-quinolinecarbonitriles were potent inhibitors of Src kinase activity. We disclose here a new highly efficient and versatile route to these compounds, which are also potent inhibitors of Abl kina

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