622381-67-3Relevant academic research and scientific papers
IRAK DEGRADERS AND USES THEREOF
-
, (2021/01/23)
The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.
CONJUGATE COMPOUNDS FOR THE DEGRADATION OF RAF
-
Paragraph 0185; 0235, (2020/08/28)
The present disclosure provides, inter alia, RAF-Degrading Conjugate Compounds that are useful in the treatment of cancer and other RAF related diseases. Also provided are, pharmaceutical compositions, methods of treatment, and kits comprising a RAF-Degrading Conjugate Compound.
IRAK DEGRADERS AND USES THEREOF
-
, (2020/06/19)
The present invention provides compounds, compositions thereof, and methods of using the same.
PIPERAZINE BENZOTHIAZOLES AS AGENTS FOR THE TREATMENT OF CEREBRAL ISCHEMIC DISORDERS OR CNS DISORDERS
-
Page/Page column 22, (2010/02/07)
The present invention is related to piperazine benzothiazole derivatives, notably for use in the treatment and/or prophylaxis of cerebral ischemic disorders or CNS disorders. The present invention is furthermore related to methods of their preparation.
