622402-63-5

Upstream product

• 272116-45-7 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-(2,4-dioxo-5-phenylsulfanylmethyl-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 75106-39-7 Acetic acid (2R,3S,5R)-2-acetoxymethyl-5-(5-acetoxymethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 5116-24-5 2'-deoxy-5-(hydroxymethyl)uridine 
• 272116-46-8 5-(phenylthiomethyl)-2'-deoxyuridine 
• 108-98-5 thiophenol 
• 108-24-7 acetic anhydride 
• 272116-56-0 5'-O-(4,4'-dimethoxytrityl)-5-(phenylthiomethyl)-2'-deoxyuridine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 
• 951-78-0 2'-deoxyuridine 

Downstream Products

• 622402-64-6 Acetic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(2-oxo-5-phenylsulfanylmethyl-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 622402-65-7 Acetic acid (2R,3S,5R)-2-hydroxymethyl-5-(2-oxo-5-phenylsulfanylmethyl-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 
• 111476-41-6 Acetic acid (2R,3S,5R)-5-(2,4-dioxo-5-phenylsulfanylmethyl-3,4-dihydro-2H-pyrimidin-1-yl)-2-methanesulfonyloxymethyl-tetrahydro-furan-3-yl ester 
• 111476-36-9 3'-O-acetyl-2',5'-dideoxy-5'-iodo-5-phenylthiomethyluridine 
• 111476-35-8 3'-O-acetyl-5-(phenylthiomethyl)-2'-deoxyuridine 

Relevant academic research and scientific papers

Independent Generation of 5-(2′-Deoxycytidinyl)methyl Radical and the Formation of a Novel Cross-Link Lesion between 5-Methylcytosine and Guanine

Reactive oxygen species (ROS) can damage DNA. Although a number of single nucleobase lesions induced by ROS have been structurally characterized, only a few intrastrand cross-link lesions have been identified and characterized, and all of them involve adj

SYNTHESIS OF 6,5'-cyclo-2',5'-DIDEOXYPYRIMIDINE NUCLEOSIDES ( NUCLEOSIDES AND NUCLEOTIDES. LXXII )

6,5'-cyclo-2',5'-dideoxyuridine and 6,5'-cyclo-5'-deoxythymidine, pyrimidine deoxynucleosides fixed in the anti conformation were synthesized.The key intermediate, 3'-O-acetyl-5-chloro-2',5'-dideoxy-5'-iodouridine ( 12 ), prepared from 2'-deoxyuridine, was cyclized by treatment with tributyltin hydride to the 6,5'-cyclo derivative ( 13 ), then dehydrochlorinated to furnish, after de-O-acetylation, 6,5'-cyclo-2',5'dideoxyuridine ( 14 ).For the synthesis of 6,5'-cyclothymidine, 3'-O-acetyl-2',5'-dideoxy-5'-iodo-5-phenylthiomethyluridine ( 22 ) was prepared from 2'-deoxyuridine and this compound was cyclized by treatment with tributyltin hydride to yield, after de-O-acetylation 6,5'-cyclo-5'-deoxythymidine ( 24 ).Keywords - cyclonucleoside; C-cyclouridine; 6,5'-cyclo-2',5'-dideoxyuridine; 6,5'-cyclo-5'deoxythymidine; 5-bromo-6,5'-cyclo-2',5'-dideoxyuridine; radical cyclization; tributyltin hydride; NMR; CD