62257-92-5Relevant articles and documents
Tocotrienamines and tocopheramines: Reactions with radicals and metal ions
Galli, Francesco,Mazzini, Francesco,Bamonti, Luca,Gille, Lars,B?hmdorfer, Stefan,Piroddi, Marta,Netscher, Thomas,Kelly, Frank J.,Rosenau, Thomas
, p. 6483 - 6491 (2011)
The antioxidant activity of vitamin E (VE) homologs a, c and d-tocotrienamines (4b-6b), never studied before, and a, c and d-tocopheramines (4a-7a) was investigated by means of different total antioxidant capacity (TAC) tests. In all the test model systems, compounds 4a-7a and 4b-6b showed similar or higher TAC values than the parental vitamin E forms and their physiological metabolites. α-Homologs of VE amines showed markedly higher activity than the VE congeners in the TEAC test, which is tailored for liposoluble antioxidants, while c-homologs of the amine analogs showed higher activity in the FRAP tests. Kinetics analysis of the reaction with DPPH showed higher second order rate k for 4a than for α-tocopherol (1a). α-Tocopherolquinone 1f was the common main oxidation product for both 1a and α-tocopheramine (4a) exposed to ferric ions or DPPH, and the implied oxidative deamination of 4a was accompanied by a nitration reaction of phenolic substrates that were added to the reaction medium. Possible mechanisms of these reactions were studied.
