62265-67-2

Usage

Chemical Properties

Light Yellow Gum

Uses

Main Quinfamide (Q670600) metabolite.

InChI:InChI=1/C11H11Cl2NO2/c12-10(13)11(16)14-5-1-2-7-6-8(15)3-4-9(7)14/h3-4,6,10,15H,1-2,5H2

Upstream product

• 79-36-7 dichloroacethyl chloride 
• 3373-00-0 6-hydroxy-1,2,3,4-tetrahydroquinoline 
• 107-06-2 1,2-dichloro-ethane 

Downstream Products

• 62265-68-3 quinfamide 
• 62265-70-7 6-benzoyloxy-1-dichloroacetyl-1,2,3,4-tetrahydro-quinoline 

Relevant academic research and scientific papers

1-(Halogenated-acetyl)-1,2,3,4-tetrahydro-6-quinolinols and esters thereof

Compounds useful as antiamebic agents are 1-(Ac1)-5-R-6-(Ac2 O)-1,2,3,4-tetrahydroquinolines (I), where Ac1 is haloacetyl, dihaloacetyl or trihaloacetyl with halo being chloro or bromo, R is hydrogen, chloro or bromo, and Ac2 is hydrogen, Ac1, alkanoyl having from one to sixteen carbon atoms, benzoyl, 2(or 3)-thenoyl, 2(or 3)-furoyl or N-(lower-alkyl)carbamoyl. Said compounds are prepared: by reacting 1,2,3,4-tetrahydro-6-quinolinol with an acyl halide of the formula Ac1 -halogen to produce 1-(Ac1)-1,2,3,4-tetrahydro-6-quinolinol having formula I where R and Ac2 are each hydrogen, Ac1 is defined as in formula I and halide is chloride or bromide; by reacting said 1-(Ac1)-1,2,3,4-tetrahydro-6-quinolinol with a chlorinating or brominating agent to produce the corresponding 1-(Ac1)-5-chloro(or bromo)-1,2,3,4-tetrahydro-6-quinolinol where Ac1 is defined as in claim 1; and, by reacting 1-(Ac1)-5-R-1,2,3,4-tetrahydro-6-quinolinol with an acylating agent providing Ac2 to produce 1-(Ac1)-5-R-1,2,3,4-tetrahydro-6-(Ac2 O)quinoline having formula I where R is hydrogen, chloro or bromo, Ac1 is defined as in formula I and Ac2 is other than hydrogen as defined in formula I.