62306-80-3

Basic information

• Product Name: 5-Formylfuran-3-boronic acid
• Synonyms: AKOS BRN-0379;5-Formylfuran-3-boronic acid;2-FORMYLFURAN-4-BORONIC ACID;5-Formyl-3-furanylboronicacid;2-Formyl-4-furanboronic Acid;5-formylfyran-3-ylboronic acid;(5-forMylfuran-3-yl)boronic acid;(5-Formylfuran-3-yl)
• CAS NO: 62306-80-3
• Molecular Formula: C₅H₅BO₄
• Molecular Weight: 139.9
• Mol File: 62306-80-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 379.3 °C at 760 mmHg
• Flash Point: 183.2 °C
• Appearance: white to light yellow crystal powder
• Density: 1.36 g/cm³
• Vapor Pressure: 1.98E-06mmHg at 25°C
• Refractive Index: 1.51
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 7.25±0.10(Predicted)
• CAS DataBase Reference: 5-Formylfuran-3-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Formylfuran-3-boronic acid(62306-80-3)
• EPA Substance Registry System: 5-Formylfuran-3-boronic acid(62306-80-3)

Safety Data

• Hazardous Substances Data: 62306-80-3(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystal powde

InChI:InChI=1/C5H5BO4/c7-2-5-1-4(3-10-5)6(8)9/h1-3,8-9H

Upstream product

• 681509-84-2 4-bromofurfural dimethyl acetal 
• 5419-55-6 Triisopropyl borate 
• 27065-51-6 2-(diethoxymethyl)-4-bromofuran 
• 7732-18-5 water 
• 915040-89-0 4-iodofurfural diethyl acetal 
• 917076-54-1 4-chlorofurfural diethyl acetal 
• 688-74-4 boric acid tributyl ester 
• 83953-42-8 4-bromo-2-furancarboxyaldehyde ethylene acetal 

Downstream Products

• 700845-77-8 7-[(2, 4-dichloro-5-methoxyphenyl) amino]-2-(5-formyl-3-furyl) thieno [3,2-b] pyridine-6-carbonitrile 
• 1137088-26-6 (5-formylfuran-3-yl)(triphenyl-λ5-phosphanyl)gold 
• 876138-04-4 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-(5-formylfuran-3-yl)-6-methoxyquinoline-3-carbonitrile 
• 1297539-90-2 4-(5-formylfuran-2-yl)-2-(trifluoromethyl)benzonitrile 

Relevant articles and documents

Preparation process for 5-formylfuran-3-boronic acid

The invention discloses a preparation process for 5-formylfuran-3-boronic acid, belonging to the technical field of synthesis of pharmaceutical intermediates. The invention aims to overcome the problem that the preparation of 5-formylfuran-3-boronic acid in the prior art is limited. According to a technical scheme in the invention, furfural acetal is used as a raw material and subjected to a metallization reaction with a metallizing agent under the action of a catalyst and under stirring; boric acid ester is added into a solvent having undergone the metallization reaction, and complete conversion is realized through stirring so as to obtain a mixture of an acetal-protected furfural-4-borate and the solvent; the mixture obtained in the previous step S2 is subjected to low-temperature distillation so as to obtain a low-boiling-point substance, the low-boiling-point substance is cooled to room temperature and then added to a perchloric acid solvent having a pH value of 0.7 to 1.1, and mixing under stirring is carried out in a low-temperature environment; a mixed solution obtained in the previous stepS3 is filtered by a needle felt to obtain a precipitate; and the precipitate is washedwith methyl isobutyl ketone and then dried under reduced pressure to obtain 5-formylfuran-3-boronic acid. The preparation process of the invention achieves the effects of high yield and high purity.