623145-39-1Relevant academic research and scientific papers
Clickable peptide nucleic acids (cPNA) with tunable affinity
Chouikhi, Dalila,Barluenga, Sofia,Winssinger, Nicolas
supporting information; experimental part, p. 5476 - 5478 (2010/10/19)
Peptide nucleic acids (PNAs) are functional analogues of natural oligonucleotides. Herein, we report the synthesis of PNAs bearing a triazole in lieu of the amide bond assembled using a "click" cycloaddition, their hybridization properties as well as the DNA-templated coupling of the azide and alkyne PNA fragments. The Royal Society of Chemistry 2010.
Azidopeptide Nucleic Acid. An Alternative Strategy for Solid-Phase Peptide Nucleic Acid (PNA) Synthesis
Debaene, Francois,Winssinger, Nicolas
, p. 4445 - 4447 (2007/10/03)
(Equation presented) A practical and efficient method for PNA synthesis using an azide group to mask the N-terminus is reported. The deprotection was carried out in 5 min, while couplings were complete within 60 min. The near neutral conditions of the pho
