623163-11-1

Basic information

• Product Name: 4-CHLORO-8-NITRO-QUINOLINE-3-CARBONITRILE
• Synonyms: 4-CHLORO-8-NITRO-QUINOLINE-3-CARBONITRILE ;3-Quinolinecarbonitrile, 4-chloro-8-nitro-
• CAS NO: 623163-11-1
• Molecular Formula: C₁₀H₄ClN₃O₂
• Molecular Weight: 233.61066
• Mol File: 623163-11-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 428.5°C at 760 mmHg
• Flash Point: 213°C
• Appearance: /
• Density: 1.55g/cm³
• Vapor Pressure: 1.51E-07mmHg at 25°C
• Refractive Index: 1.692
• CAS DataBase Reference: 4-CHLORO-8-NITRO-QUINOLINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-8-NITRO-QUINOLINE-3-CARBONITRILE(623163-11-1)
• EPA Substance Registry System: 4-CHLORO-8-NITRO-QUINOLINE-3-CARBONITRILE(623163-11-1)

Safety Data

• Hazardous Substances Data: 623163-11-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H4ClN3O2/c11-9-6(4-12)5-13-10-7(9)2-1-3-8(10)14(15)16/h1-3,5H

Relevant articles and documents

QUINOLINE DERIVATIVES AS CASPASE-3 INHIBITOR, PREPARATION FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to new quinoline derivatives of formula (1) or their pharmaceutically acceptable salts with caspase-3 inhibitory activity and their preparation methods, wherein R2 is H; halogen; C1-6alkyl; C 1-6 alkoxy; C1-6 alkoxyalkyl; or C3-6cycloalkyl; R1 is formula (a); -CN; or formula (b); R is H; C6-14aryl unsubstituted or substituted by halogen, C1-6 alkyl, C1-6 alkoxy or amino; 5 - 15 membered heterocyclic group unsubstituted or substituted by halogen, C1-6 alkyl, C1-6 alkoxy or amino; or -(CH2)n-CHR4R5. The present invention relates to a pharmaceutical composition for treating caspase-associated diseases by inhibiting the activity of caspase-3 which comprises the compound of formula (1) or its pharmaceutically acceptable salt.