623167-12-4Relevant academic research and scientific papers
Experimental evidence for intramolecular ipso substitution of alkyl groups
Zubkov, Fedor I.,Nikitina, Eugenia V.,Kouznetsov, Vladimir V.,Duarte, Luz Dary Avellaneda
, p. 5064 - 5074 (2007/10/03)
An acid-mediated intramolecular Friedel-Crafts intramolecular alkene alkylation of the ortho-alkyl group in the N-aryl-amino moiety of various N-(1-allylcycloalkyl)-N-arylamines resulting in alkyl-substituted 3′,4′-dihydro-1′H-spiro[cycloalkane-1,2′-quino
In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers
Vargas M., Leonor Y.,Castelli, Maria V.,Kouznetsov, Vladimir V.,Urbina G., Juan M.,Lopez, Silvia N.,Sortino, Maximiliano,Enriz, Ricardo D.,Ribas, Juan C.,Zacchino, Susana
, p. 1531 - 1550 (2007/10/03)
The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-β-D-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.
