62325-94-4Relevant academic research and scientific papers
Synthesis and biological evaluation of some undecanone derivatives
Meka, Bharani,Ravada, Suryachandra Rao,Kancharla, Harikrishna,Golakoti, Trimurtulu
, p. 3106 - 3124 (2017/10/06)
The total synthesis of Ardisinone E [15, 1-(2,4,6-trihydroxy phenyl)-11-(2-hydroxyphenyl)-undecan-1-one], a natural diarylundecanone, isolated from Ardisia arborescens, was accomplished along with 16 new diarylundecanone analogs (18a–p), by modified Wittig reaction. The structures of the compounds were confirmed by 1H, 13C and mass spectral data. Compound 15 showed potent cytotoxic activity with an ED50 of 4.19 μg/mL in brine shrimp lethality assay model. Compounds 18c, 18e, 18j, 18k, 18l, and 18m exhibited strong anti-oxidant activity with IC50 values of 18.75, 12.28, 18.35, 11.04, 12.05, and 11.32 μg/mL, respectively, in NBT free radical assay. Compounds 18e, 18k, and 18m also showed significant 5-lipoxyganase enzyme inhibitory potential with IC50 values of 12.8, 15.23, and 15.23 μg/mL, respectively.
Antivital activity of some β diketones. I. Aryl alkyl diketones. In vitro activity against both RNA and DNA viruses
Diana,Salvador,Zalay,et al.
, p. 750 - 756 (2007/10/05)
The discovery that 4 [3 ethyl 6 [(3,4 methylenedioxy)phenyl] 3 hexenyl] 3,5 heptanedione exhibited an in vitro inhibitory effect against equine rhinovirus led to a structure activity study to establish the criteria for optimum activity. Modification of th
