62327-21-3

Basic information

• Product Name: tert-Butyl O,O-dimethylphosphonoacetate
• Synonyms: tert-Butyl P,P-diMethylphosphonoacetate, >= 97.0 % GC;tert-Butyl ((oxo)dimethoxyphosphino)acetate;tert-Butyl (dimethoxyphosphinyl)acetate;tert-Butyl 2-(dimethoxyphosphoryl);TERT-BUTYL P,P-DIMETHYLPHOSPHONOACETATE;DIMETHYL TERT-BUTOXYCARBONYL-METHYLPHOSPHONATE;tert-Butyl O,O-dimethylphosphonoacetate;tert-Butyl dimethylphosphonoacetate
• CAS NO: 62327-21-3
• Molecular Formula: C₈H₁₇O₅P
• Molecular Weight: 224.19
• Mol File: 62327-21-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 86-87 °C0.02 mm Hg(lit.)
• Flash Point: 110 ºC
• Appearance: /
• Density: 1.131 g/mL at 20 °C(lit.)
• Vapor Pressure: 0.00505mmHg at 25°C
• Refractive Index: n20/D 1.434
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• BRN: 4861886
• CAS DataBase Reference: tert-Butyl O,O-dimethylphosphonoacetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl O,O-dimethylphosphonoacetate(62327-21-3)
• EPA Substance Registry System: tert-Butyl O,O-dimethylphosphonoacetate(62327-21-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• F: 9-23
• Hazardous Substances Data: 62327-21-3(Hazardous Substances Data)

Usage

Uses

Reactant for:Preparation of phosphonate terminated PPH dendrimers as anti-HIV-1 agentsPreparation of monodehydro diketopiperazines from ketoacyl amino acid amides via acid-catalyzed cyclizationPreparation of α,β-unsaturated esters for use in the guanidine-catalyzed oxa-Michael additionPreparation of myxopyronin B and desmethyl myxopyronin B analogs, with antibacterial activity and inhibitory activity against bacterial RNA polymeraseAllylation and subsequent ring-closing metathesis in presence of Grubbs′ catalyst or intramolecular rhodium-catalyzed cyclopropanation reactions

InChI:InChI=1/C8H17O5P/c1-8(2,3)13-7(9)6-14(10,11-4)12-5/h6H2,1-5H3

Upstream product

• 5927-18-4 trimethyl phosphonoacetate 
• 865-47-4 potassium tert-butylate 

Downstream Products

• 62327-22-4 (E)-3-(4-Hydroxy-2-methyl-cyclohex-1-enyl)-acrylic acid tert-butyl ester 
• 92591-97-4 t-butyl (benzyl 5,6-dideoxy-6-dimethoxyphosphoryl-2,3-O-isopropylidene-α-D-lyxo-heptofuranosid)uronate 
• 403705-03-3 tert-butyl (E)-3-(2-iodophenyl)prop-2-enoate 
• 918299-61-3 C₃₈H₃₉N₂O₁₃P 
• 932367-99-2 C₂₈H₃₂F₃NO₄ 
• 932367-98-1 C₂₉H₃₄F₃NO₄ 
• 945039-15-6 C₂₇H₃₀F₃NO₄ 
• 945039-13-4 C₂₉H₃₄F₃NO₄ 

Relevant articles and documents

CARBAMOYL COMPOUNDS AS DGAT1 INHIBITORS 190

DGAT-1 inhibitor compounds of formula (I), pharmaceutically-acceptable salts and pro- drugs thereof are described, together with pharmaceutical compositions, processes for making them and their use in treating, for example, obesity wherein, for example, Ring A is optionally substituted 2,6-pyrazindiyl; X is =O; Ring B is optionally substituted 1,4-phenylene; Y1 is a direct bond or -O-; Y2 is -(CH 2) r- wherein r is 2 or 3; n is 0 or n is 1 when Y1 is a direct bond between Ring B and Ring C and when Ring B is 1,4-phenylene and Ring C is (4-6C)cycloalkane; Ring C is optionally substituted (4-6C)cycloalkane, (7-10C)bicycloalkane, (8-12C)tricycloalkane, phenylene or pryidindiyl; L is a direct bond or -O-; p is 0, 1 or 2 and when p is 1 or 2 RA1 and RA2 are each independently hydrogen or (1-4C)alkyl; Z is carboxy or a mimic or bioisostere thereof.