62334-09-2

Usage

InChI:InChI=1/C10H9NO3/c12-6-11-4-3-8-1-2-9-10(5-8)14-7-13-9/h1-2,5H,3-4,7H2

Upstream product

• 68996-81-6 3-benzo[1,3]dioxol-5-yl-propionyl chloride 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1484-85-1 3,4-methylenedioxyphenylethylamine 
• 191847-31-1 (2-benzo[1,3]dioxol-5-yl-ethyl) carbaminic acid tert-butyl ester 
• 2815-95-4 3-(1,3 benzodioxol-5-yl)propionic acid 

Downstream Products

• 1056637-37-6 C₂₈H₂₇N₃O₅ 
• 6882-28-6 norhydrastinine 

Relevant academic research and scientific papers

Synthesis of 3,4-dihydroisoquinolin-1-ones from N-Boc-(β-Arylethyl) carbamates via isocyanate intermediates

Mild reaction conditions for the regioselective synthesis of isoquinolin-1-ones and related fused-ring heterocycles from N-Boc-protected (β-arylethyl)carbamates are described. The reactions involved the use of Tf2O and 2-chloropyridine and isocyanates are likely to be key intermediates. The method was extended to substrates bearing less nucleophilic aryl moieties by using Lewis acid additives, such as BF3· Et2O, to enhance the Friedel-Crafts-type cyclization of the isocyanate intermediates. This method allowed the synthesis of various substituted isoquinolin-1-ones, β-carbolines, thiophene-fused ring systems and tetrahydrobenzoazepin-1-ones in good yields and with high regioselectivities. Copyright

Synthesis and evaluation of novel compounds as potent dipeptidyl peptidase IV inhibitors

A series of new 2-cyanopyrrolidine derivatives with constrained imidazolidin ring were synthesized, Their structures were confirmed by 1H NMR spectroscopy and/or mass spectrometry, and their activities were evaluated in vitro. They were proven to possess submicromolar inhibitory activities against dipeptidyl peptidase IV.

Efficient synthesis of tetrahydro-b-carbolin-1-one and dihydroisoquinolin- 1-one derivatives as versatile Intermediates

An efficient one-pot procedure is described in which an isocyanate intermediate, generated from the corresponding carboxylic acid by a modified Curtius rearrangement, is captured by a tethered aromatic ring in the presence of BF3?OEt2 to generate various

Synthesis of phthalideisoquinolines from 3-halophthalides and 3,4-dihydroisoquinolinium salts

Phthalideisoquinoline alkaloids have been synthesized by coupling appropriately substituted 3-halophthalides and 2-methyl-3,4-dihydroisoquinolinium salts in the presence of Zn(Cu) couple or metallic Zn.Both erythro and threo isomers are formed in the reaction.The nmr spectra of the (+/-)-erythro- and (+/-)-threo-isocordrastines have been reinvestigated.The results, which differ from those previously reported, lead to a different conclusion regarding the conformations of the molecules.