62334-22-9

Basic information

• Product Name: N-(2,2-diethoxyethyl)-1-(3,4-dimethoxyphenyl)propan-1-amine
• CAS NO: 62334-22-9
• Molecular Weight: 311.422
• Mol File: 62334-22-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2,2-diethoxyethyl)-1-(3,4-dimethoxyphenyl)propan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2-diethoxyethyl)-1-(3,4-dimethoxyphenyl)propan-1-amine(62334-22-9)
• EPA Substance Registry System: N-(2,2-diethoxyethyl)-1-(3,4-dimethoxyphenyl)propan-1-amine(62334-22-9)

Safety Data

• Hazardous Substances Data: 62334-22-9(Hazardous Substances Data)

Upstream product

• 58163-19-2 Veratryliden-aminoacetaldehyd-diethylacetal 
• 925-90-6 ethylmagnesium bromide 

Relevant articles and documents

SUBSTITUTED 6, 7-DIALKOXY-3-ISOQUINOLINE DERIVATIVES AS INHIBITORS OF PHOSPHODIESTERASE 10 (PDE 10A)

The invention relates to compounds of the formula or a pharmaceutically acceptable salt thereof, wherein R′, R1 through R7 and Ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (PDE10A) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type II diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases.

A ONE-POT ISOQUINOLINE SYNTHESIS BY CYCLODEHYDROGENATION OF BENZYLAMINOACETALS WITH CHLOROSULFONIC ACID

A direct preparation of the fully aromatized isoquinolines (3a-l) by the cyclodehydrogenation of benzylamnoacetals (2a-l) with chlorosulfonic acid is described.Comparing the behavior of chlorosulfonic acid with that of sulfuric acid toward 1,2-dihydroisoquinoline, it is able to be suggested that benzylaminoacetals were cyclized first to 1,2-dihydroisoquinolines, subsequently, dehydrogenated to the fully aromatized isoquinolines by the hydride abstraction with ClSO3H.Subtitution by a larger R3 group than isopropyl in the acetal ArCH(R3)NHCH2CH(OEt)2, interfered this second step, so the corresponding isoquinolines could not be obtained.