62337-05-7

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 28004-54-8 5-[(E)-2-phenylethenyl]-1,3,4-thidiazol-2-amine 
• 3673-31-2 trans-cinnamaldehyde-(4-methyl-thiazol-2-ylhydrazone) 
• 114554-95-9 thiazolidine-2,4-dione-2-trans-cinnamylidenehydrazone 
• 1290545-10-6 [(benzyl)3tin(IV)(cinnamaldehyde thiosemicarbazone(-H))] 
• 1424370-36-4 C₁₉H₂₁N₃O 
• 1424370-08-0 (E)-4-(3-methoxyphenethyl)-3-styryl-4H-1,2,4-triazole 
• 1424370-43-3 C₁₉H₂₁N₃O 
• 1424370-12-6 (E)-4-(4-methoxyphenethyl)-3-styryl-4H-1,2,4-triazole 

Relevant academic research and scientific papers

Antibacterial activity of metal complexes based on cinnamaldehyde thiosemicarbazone analogues

The development of microbial antibiotic resistance has become one of the biggest threats to global health and the search for new molecules active against resistant pathogenic strains is a challenge that must be tackled. In many cases nosocomial infections

Antityrosinase and antimicrobial activities of frans- cinnamaldehydethiosemicarbazone

Tyrosinase (EC 1. 14. 18. 1) is a key enzyme in pigment biosynthesis of organisms. frans-Cinnamaldehyde thiosemicarbazone, a derivative of benzaldehyde thiosemicarbazone, was synthesized as an inhibitor of tyrosinase. The inhibitory effects of this compou

Synthesis, spectral characterization and DNA interactions of 5-(4-substituted phenyl)-1,3,4-thiadiazol-2-amine scaffolds

Five 5-(4-Substituted phenyl)-1, 3, 4-thiadiazole-2-amines have been prepared and structure of the compounds confirmed by spectroscopy studies. On the basis of spectroscopic studies, confirmed the formation of compounds. The DNA binding affinity of the prepared compounds was undertaken by absorption titration method and increasing the amount of CT-DNA observed hyperchromism or hypsochromism. The binding affinity compounds (except 5) are in the order of 4[13.341 × 104 M?1]>3 [8.505 × 104 M-1]>2 [3.567 × 104 M-1]>1[3.525 × 104 M?1]. The ethidiumbromide quenching results indicates CT-DNA was quenched by thiadiazoles via a static quenching mechanism. The DNA cleavage studies of the compounds were carried out in the presence and absence of H2O2 using gel electrophoresis experiment.

Regioselective N(2)-H-functionalization of thiosemicarbazones of aromatic and heteroaromatic aldehydes with acrylonitrile

Regioselective N(2)-H-cyanoethylation of thiosemicarbazones of aromatic and heteroaromatic aldehydes with acrylonitrile proceeds under mild conditions (14% KOH, acetone/H2O, 35 °C, 6–21 h) to afford 1-(2-сyanoethyl)-2-[(E)-aryl(heteroaryl)methylidene]-1-hydrazinecarbothioamides in up to 74% yields. The synthesized thioamides are promising precursors of novel families of functionalized thiosemicarbazones as exemplified by hydrolysis of their cyano group to the corresponding amido function (46.5–60% yields).

In vitro evaluation of the activity of thiosemicarbazone derivatives against mycotoxigenic fungi affecting cereals

With a steadily increasing world population, a more efficient system of food production is of paramount importance. One of the major causes of food spoilage is the presence of fungal pathogens and the production and accumulation of mycotoxins. In the pres

Synthesis of 2-amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via sequential condensation and I2-mediated oxidative C-O/C-S bond formation

2-Amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles were synthesized via condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes followed by I2-mediated oxidative C-O/C-S bond formation. This transition-metal-free sequential synthesis process is compatible with aromatic, aliphatic, and cinnamic aldehydes, providing facile access to a variety of diazole derivatives bearing a 2-amino substituent in an efficient and scalable fashion.