62349-04-6

Upstream product

• 110-89-4 piperidine 
• 60442-41-3 2-chloroacetylamino-3-carbethoxy-4,5,6,7-tetrahydrobenzothiophene 
• 4506-71-2 ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate 
• 6802-76-2 ethyl 2-cyano-2-cyclohexylideneacetate 
• 108-94-1 cyclohexanone 
• 50618-83-2 2-(1-piperidinyl)acetyl chloride 
• 105-56-6 ethyl 2-cyanoacetate 

Relevant academic research and scientific papers

Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3- c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action

SAR studies were performed on a series of 2-arylamido-5,7-dihydro-4H- thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists. Starting from a HTS hit both potency and selectivity could be improved. Modifications to the thiophene fusion and C-3 amides were studied. A representative compound 3t produced analgesia when dosed orally in inflammatory pain models of writhing and carrageenan-induced allodynia.

Novel anthelmintic and insecticidal compositions

Novel anthelmintic compositions containing thiophene derivatives as active ingredients are disclosed.

ANTHELMINTIC AND INSECTICIDAL THIOPHENE DERIVATIVES

Novel anthelmintic compositions containing thiophene derivatives as active ingredients are disclosed.

Synthesis and local anaesthetic activity of some 2-aminoacetylamino-3-carbetoxy/anilido-4,5,6,7-tetrahydro-benzothiophenes

Twenty new 2-substituted aminoacetylamino-3-carbetoxy/anilido-4,5,6,7-tetrahydrobenzothiophenes (4a-4t) have been synthesised with a view to studying the effect of structural modification of carticaine (B) on the local anaesthetic activity and evaluated by Sollman's method as well as Bulbring and Wajda method using lignocaine hydrochloride as a standard.All the tested compounds show moderate to good activity and 4a has been found to be the most active drug comparable to the standard.