623564-36-3 Usage
Description
8H-Imidazo[2,1-c][1,4]thiazine-3-carboxaldehyde,5,6-dihydro-(9CI) is a heterocyclic chemical compound that belongs to the imidazo-thiazine family. It features an imidazole ring fused to a thiazine ring, with a carboxaldehyde group at position 3 and 5,6-dihydro substitution. This unique structure and functional groups endow it with potential biological activity, making it a promising candidate for pharmaceutical and medicinal chemistry applications.
Uses
Used in Pharmaceutical Industry:
8H-Imidazo[2,1-c][1,4]thiazine-3-carboxaldehyde,5,6-dihydro-(9CI) is used as a pharmaceutical intermediate for the synthesis of various drug candidates. Its unique structure and functional groups allow for the development of new compounds with potential therapeutic effects.
Used in Medicinal Chemistry Research:
8H-Imidazo[2,1-c][1,4]thiazine-3-carboxaldehyde,5,6-dihydro-(9CI) serves as a key building block in the design and synthesis of novel bioactive molecules. Researchers and scientists can utilize its properties to explore its potential in drug development, targeting various diseases and conditions.
Used in Drug Discovery:
8H-Imidazo[2,1-c][1,4]thiazine-3-carboxaldehyde,5,6-dihydro-(9CI) is employed as a starting material in drug discovery processes. Its unique structure and functional groups can be further modified and optimized to develop new drugs with improved efficacy, selectivity, and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 623564-36-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,3,5,6 and 4 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 623564-36:
(8*6)+(7*2)+(6*3)+(5*5)+(4*6)+(3*4)+(2*3)+(1*6)=153
153 % 10 = 3
So 623564-36-3 is a valid CAS Registry Number.
623564-36-3Relevant articles and documents
Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum β-lactamase inhibitors: Evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods
Venkatesan, Aranapakam M.,Agarwal, Atul,Abe, Takao,Ushirogochi, Hideki,Yamamura, Itsuka,Ado, Mihira,Tsuyoshi, Takasaki,Dos Santos, Osvaldo,Gu, Yansong,Sum, Fuk-Wah,Li, Zhong,Francisco, Gerry,Lin, Yang-I.,Petersen, Peter J.,Yang, Youjun,Kumagai, Toshio,Weiss, William J.,Shlaes, David M.,Knox, James R.,Mansour, Tarek S.
, p. 4623 - 4637 (2007/10/03)
The design and synthesis of a series of 6-methylidene penems containing [6,5]-fused bicycles (thiophene, imidazole, or pyrazle-fused system) as novel class A, B, and C β-lactamase inhibitors is described. These penems proved to be potent inhibitors of the TEM-1 (class A) and AmpC (class C) β-lactamases and less so against the class B metallo-β-lactamase CcrA. Their in vitro and in vivo activities in combination with piperacillin are discussed. On the basis of the crystallographic structures of a serine-bound reaction intermediate of 2 with SHV-1 (class A) and GC1 (class C) enzymes, compounds 14a-1 were designed and synthesized. Penems are proposed to form a seven-membered 1,4 thiazepine ring in both class A and C β-lactamases. The interaction energy calculation for the enzyme-bound intermediates favor the formation of the C7 R enantiomer over the S enantiomer of the 1,4-thiazepine in both β-lactamases, which is consistent with those obtained from the crystal structure of 2 with SHV-1 and GC1.
PROCESS FOR PREPARING 6-ALKYLIDENE PENEM DERIVATIVES
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Page/Page column 78-79, (2010/02/07)
The present invention provides a process of making compounds of Formula (I), which are useful for the treatment of bacterial infection or disease.
