623564-49-8

Basic information

• Product Name: (4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIDIN-2-YL)METHANOL
• Synonyms: (4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIDIN-2-YL)METHANOL
• CAS NO: 623564-49-8
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.2
• Mol File: 623564-49-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIDIN-2-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIDIN-2-YL)METHANOL(623564-49-8)
• EPA Substance Registry System: (4,5,6,7-TETRAHYDROPYRAZOLO[1,5-A]PYRIDIN-2-YL)METHANOL(623564-49-8)

Safety Data

• Hazardous Substances Data: 623564-49-8(Hazardous Substances Data)

Usage

General Description

(4,5,6,7-Tetrahydropyrazolo[1,5-a]pyridin-2-yl)methanol is a chemical compound that has a pyrazole ring and a pyridine ring in its structure. It is a synthetic compound that is commonly used in medicinal chemistry and drug discovery research. The compound is an alcohol derivative and is often used as a building block for the synthesis of various pharmaceutical compounds. It has potential pharmacological properties and is being investigated for its potential use in the treatment of various diseases. The compound's unique molecular structure makes it a valuable tool for researchers in the field of medicinal chemistry.

Upstream product

• 307313-03-7 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid 
• 3105-95-1 pipecolinic acid 
• 307307-82-0 methyl 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylate 
• 30310-83-9 N-nitroso-L-pipecolic acid 
• 4043-87-2 pipecolic Acid 
• 4515-18-8 1-nitroso-piperidine-2-carboxylic acid 
• 105786-95-6 4,5,6,7-tetrahydro<1.2.3>oxadiazolo<3,4-a>pyridin-3-one 
• 307307-84-2 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carboxylic acid ethyl ester 

Downstream Products

• 307313-06-0 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-2-carbaldehyde 
• 1025959-41-4 6-[acetoxy-(4,5,6,7-tetrahydro-pyrazolo[1,5-a]pyridin-2-yl)-methyl]-6-bromo-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Relevant articles and documents

MACROCYCLIC COMPOUNDS

The present application discloses compounds of Formula (I). Such compounds, pharmaceutically acceptable salts and compositions thereof, are inhibitors of Mcl-1 proteins and are useful in treating diseases and conditions characterized by excessive cellular proliferation such as cancer.

MACROCYCLIC COMPOUNDS

Disclosed are macrocyclic compounds of formula (I) comprising a 2-carboxy indole ring. Such compounds, and their pharmaceutically acceptable salts, are useful as Mcl-1 (myeloid cell leukemia-1) inhibitors. The compounds may be used in treating a disease o

Structure-activity relationship of 6-methylidene penems bearing 6,5 bicyclic heterocycles as broad-spectrum β-lactamase inhibitors: Evidence for 1,4-thiazepine intermediates with C7 R stereochemistry by computational methods

The design and synthesis of a series of 6-methylidene penems containing [6,5]-fused bicycles (thiophene, imidazole, or pyrazle-fused system) as novel class A, B, and C β-lactamase inhibitors is described. These penems proved to be potent inhibitors of the TEM-1 (class A) and AmpC (class C) β-lactamases and less so against the class B metallo-β-lactamase CcrA. Their in vitro and in vivo activities in combination with piperacillin are discussed. On the basis of the crystallographic structures of a serine-bound reaction intermediate of 2 with SHV-1 (class A) and GC1 (class C) enzymes, compounds 14a-1 were designed and synthesized. Penems are proposed to form a seven-membered 1,4 thiazepine ring in both class A and C β-lactamases. The interaction energy calculation for the enzyme-bound intermediates favor the formation of the C7 R enantiomer over the S enantiomer of the 1,4-thiazepine in both β-lactamases, which is consistent with those obtained from the crystal structure of 2 with SHV-1 and GC1.