623564-65-8

Basic information

• Product Name: 4,5-Dihydro-6-thia-1,7a-diaza-indene-2-carboxylic acid ethyl ester
• Synonyms: 4,5-Dihydro-6-thia-1,7a-diaza-indene-2-carboxylic acid ethyl ester
• CAS NO: 623564-65-8
• Molecular Formula: C9H12N2O2S
• Molecular Weight: 212.26878
• Mol File: 623564-65-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,5-Dihydro-6-thia-1,7a-diaza-indene-2-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-Dihydro-6-thia-1,7a-diaza-indene-2-carboxylic acid ethyl ester(623564-65-8)
• EPA Substance Registry System: 4,5-Dihydro-6-thia-1,7a-diaza-indene-2-carboxylic acid ethyl ester(623564-65-8)

Safety Data

• Hazardous Substances Data: 623564-65-8(Hazardous Substances Data)

Upstream product

• 329769-27-9 4H,6H-thiazolo[3,4-c][1,2,3]oxadiazol-7-ium-3-olate 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 623564-67-0 (4H,6H-pyrazolo[1,5-c]thiazol-2-yl)methanol 

Relevant articles and documents

Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors

This invention relates to certain bicyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with β-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of general formula I or a pharmaceutically acceptable salt or in vivo hydrolyzable ester R5 thereof: wherein: One of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X═O or S.

BICYCLIC 6-ALKYLIDENE-PENEMS AS ?-LACTAMASES INHIBITORS

The present invention provides a compound of Formula (I), pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.