623565-51-5

Basic information

• Product Name: 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(acetyloxy)(2,3-dihydropyrazolo[5,1-b]oxazol-6-yl)methyl]-6-bromo-7- oxo-, (4-nitrophenyl)methyl ester, (5R)-
• CAS NO: 623565-51-5
• Molecular Formula: C21H17BrN4O8S
• Molecular Weight: 565.358
• Mol File: 623565-51-5.mol

Chemical Properties

• CAS DataBase Reference: 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(acetyloxy)(2,3-dihydropyrazolo[5,1-b]oxazol-6-yl)methyl]-6-bromo-7- oxo-, (4-nitrophenyl)methyl ester, (5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(acetyloxy)(2,3-dihydropyrazolo[5,1-b]oxazol-6-yl)methyl]-6-bromo-7- oxo-, (4-nitrophenyl)methyl ester, (5R)-(623565-51-5)
• EPA Substance Registry System: 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(acetyloxy)(2,3-dihydropyrazolo[5,1-b]oxazol-6-yl)methyl]-6-bromo-7- oxo-, (4-nitrophenyl)methyl ester, (5R)-(623565-51-5)

Safety Data

• Hazardous Substances Data: 623565-51-5(Hazardous Substances Data)

Upstream product

• 623565-50-4 2,3-dihydropyrazolo[5,1-b][1,3]oxazole-6-carbaldehyde 
• 108-24-7 acetic anhydride 
• 623564-16-9 (5R,6S)-6-bromo-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitrobenzyl ester 

Relevant articles and documents

Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors

This invention relates to certain bicyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with β-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of general formula I or a pharmaceutically acceptable salt or in vivo hydrolyzable ester R5 thereof: wherein: One of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X═O or S.

BICYCLIC 6-ALKYLIDENE-PENEMS AS ?-LACTAMASES INHIBITORS

The present invention provides a compound of Formula (I), pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.