623574-61-8Relevant academic research and scientific papers
Synthesis of 3,3′-(1-piperidino)substituted methylene-bis-isoxazoles preventing stimulus-induced leukocytes activation
Mazzei,Nieddu,Melloni,Minafra
, p. 121 - 127 (2003)
Some 3,3′-(1-piperidino)substituted methylene-bis-isoxazoles were prepared via Mannich base and tested to verify their antiinflammatory-related activity. Human neutrophils stimulated with either PMA and f-MLP were used as the cellular model. The efficiency of eight differently substituted compounds (2-9) was established on their capacity to reduce the O2- production by activated human neutrophils. The rising hydrophobicity in the side-chain of methylene-bis-isoxazoles leads to a distinction in the neutrophil response against the two stimuli, favoring the inhibition of the PMA elicited cell activation and leaving inaffected the f-MLP induced cell responses. Compounds 8 and 9 are particularly active and abolish almost completely the neutrophil activation in the presence of PMA stimulus.
