623577-48-0

Basic information

• Product Name: 5-(4-fluorophenyl)-4-methylthiazole
• Synonyms: 5-(4-fluorophenyl)-4-methylthiazole
• CAS NO: 623577-48-0
• Molecular Weight: 193.245
• Mol File: 623577-48-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 5-(4-fluorophenyl)-4-methylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)-4-methylthiazole(623577-48-0)
• EPA Substance Registry System: 5-(4-fluorophenyl)-4-methylthiazole(623577-48-0)

Safety Data

• Hazardous Substances Data: 623577-48-0(Hazardous Substances Data)

Upstream product

• 693-95-8 4-Methylthiazole 
• 352-34-1 4-fluoro-1-iodobenzene 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 20485-41-0 4-methylthiazole-5-carboxylic acid 

Relevant articles and documents

A convenient phosphine-free palladium-catalyzed direct arylation of thiazole under mild aerobic conditions

A series of bulky amine palladium complexes {[(Ar-NH2)2PdCl2]} were synthesized and characterized. The catalytic activity of the palladium complexes was evaluated via the direct C-H arylation of thiazoles with aryl bromide

Ferrocenyl palladacycles derived from unsymmetrical pincer-type ligands: Evidence of Pd(0) nanoparticle generation during the Suzuki-Miyaura reaction and applications in the direct arylation of thiazoles and isoxazoles

A new family of ferrocenyl-palladacycle complexes Pd(L1)Cl (Pd1) and Pd(L2)Cl (Pd2) were synthesized and characterized by UV-visible, IR, ESI-MS, and NMR spectral studies. The molecular structures of Pd1 and Pd2 were determined by X-ray crystallographic studies. Palladacycle catalyzed Suzuki-Miyaura cross-coupling reactions were investigated utilizing the derivatives of phenylboronic acids and substituted chlorobenzenes. Mechanistic investigation authenticated the generation of Pd(0) nanoparticles during the catalytic cycle and the nanoparticles were characterized by XPS, SEM and TEM analysis. Direct C-H arylation of thiazole and isoxazole derivatives employing these ferrocenyl-palladacycle complexes was examined. The reaction model for the arylation reaction implicating the in situ generation of Pd(0) nanoparticles was proposed.

Camphyl-based α-diimine palladium complexes: Highly efficient precatalysts for direct arylation of thiazoles in open-air

Based on the strategy of the development of phosphine-free palladium-catalyzed direct C-H arylation, a series of camphyl-based α-diimine palladium complexes bearing sterically bulky substituents were synthesized and characterized. The palladium complexes