6237-22-5Relevant articles and documents
REACTIONS AT C-9 OF ACRIDINE DERIVATIVES. PART XXVIII. KINETICS OF 1-, 2-, 3- AND 4-NITRO-9-AMINOACRIDINE SYNTHESES. SUBSTITUENT EFFECT OF THE NO2 GROUP DURING AMINOLYSIS
Kunikowski, Antoni,Ledochowski, Andrzej
, p. 435 - 445 (2007/10/02)
Spectrophotometric studies on dimethylaminopropylamine (DMAPA) reactions with 1-, 2-, 3- and 4-nitro-9-chloro(phenoxy)acridines were carried out in DMSO and in xylene.Reactions in DMSO were of the second order, with nitro isomers reacting in the sequence of 2>4>1ca.3; reactions in xylene were of the third order, with nitro isomers reacting in the sequence of 2>1>4>3; α-pyridone and triethylamine produced no catalytic effect.These data might suggest strong "para" type nitro activation for the 2-nitro isomer and significant steric interactions by nitro group to 1-nitro isomer aminolysis.