62370-45-0Relevant academic research and scientific papers
New approaches for the synthesis of heterocyclic compounds derived from cyclohexan-1,3-dione with anti-proliferative activities
Masoud, Ayat Ali,Milad, Yara Raafat,Mohareb, Rafat Milad
, p. 72 - 87 (2021/06/07)
In the present work a series of heterocyclization reactions were adopted using cyclohexan-1,3-dione through its reaction with either furan-2-carbaldehyde or thiophene-2-carbaldehyde to give the corresponding ylidene derivatives 3a,b. The latter compounds underwent heterocyclization reactions to give thiophene and pyran derivatives 5a–d and 6a–d, respectively. Moreover, compounds 3a,b reacted with elemental sulfur and phenyl isothiocyanate to give the fused thiazole derivatives 8a,b. In addition, the reaction with either of hydrazine hydrate or phenylhydrazine has given the 4-hydrazo-no-4,5,6,7-tetrahydro-2H-indazole derivatives 10a–d, respectively. Similarly, the reaction of either 3a or 3b with hydroxylamine hydrochloride gave the 6,7-dihydrobenzo[c]isoxazol-4(5H)-one oxime derivatives 12a and 12b, respectively. Other fused heterocyclic compounds were produced and their structures were elucidated. Evaluation of the synthesized compounds against selected cancer cell lines was performed. The most active compounds were further evaluated against tyrosine kinases and Pim-1 kinase inhibitions.
Metal-free coupling/isomerization reaction of isocyanide and cyclic 1,3-dione: A selective Csp3-H functionalization strategy for C-C bond formation
Jiang, Hui,Li, Jian,Li, Yefei,Sun, Mingming,Yao, Jun
supporting information, (2020/08/28)
A metal-free oxidative coupling/isomerization reaction of isocyanide and cyclic 1, 3-dione has been disclosed. In the presence of di-tert-butylperoxide (DTBP), a series of isocyanides are subjected to reaction with subsituted 1, 3-diones for direct synthe
Silver-Catalyzed Cross-Coupling of Isocyanides and Active Methylene Compounds by a Radical Process
Liu, Jianquan,Liu, Zhenhua,Liao, Peiqiu,Zhang, Lin,Tu, Tao,Bi, Xihe
supporting information, p. 10618 - 10622 (2015/09/02)
Isocyanides are versatile building blocks, and have been extensively exploited in C-H functionalization reactions. However, transition-metal-catalyzed direct C-H functionalization reactions with isocyanides suffer from over-insertion of isocyanides. Repor
