6238-15-9Relevant academic research and scientific papers
Synthesis of tritium labelled (R) and (S)-3-aminoquinuclidine: A ubiquitous component of serotonin receptor ligands, part I
Masjedizadeh, Mohammad R.,Parnes, Howard
, p. 41 - 51 (1996)
(R) and (S)-3-aminoquinuclidines-3H with the specific activity of 35 Ci/mmol were prepared. Reduction of enamide 2 with carrier free tritium gas over RhCODCl dimer, (2S, 3S) Chiraphos in methanol gave racemic amide 9c. Hydrolysis followed by resolution of the enantiomers with (R)-methyl benzyl isocyanate gave (R) and (S)-3-aminoquinuclidine-3H 10c-S and 10c-R. The enantiopurity purity of both isomers was >99.5%.
3-Amidoquinuclidine derivatives: Synthesis and interaction with butyrylcholinesterase
Odzak, Renata,Primozic, Ines,Tomic, Srdanka
, p. 101 - 107 (2008/02/05)
Racemates as well as (R)- and (S)-enantiomers of 3-pivalamidoquinuclidine (PivQ) and 3-acetamidoquinuclidine (AcQ) were prepared. Their quaternary racemic and enantiomerically pure N-benzyl derivatives (BnlPivQ and BnlAcQ) were synthesized as well. The am
Preparation of S-(-)- and R-(+)-N-(quinuclidinyl-3)-amide
-
, (2008/06/13)
Optical active forms of the carboxylic acid amines of 3-aminoquinuclidine of formula (I), and the preparation thereof. These can be hydrolysed to the optical active forms of 3-aminoquinuclidine.
