623906-33-2

Basic information

• Product Name: 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(acetyloxy)-4H,6H-pyrazolo[1,5-c]thiazol-2-ylmethyl]-6-bromo-7-oxo-, (4-nitrophenyl)methyl ester, (5R)-
• CAS NO: 623906-33-2
• Molecular Formula: C21H17BrN4O7S2
• Molecular Weight: 581.425
• Mol File: 623906-33-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(acetyloxy)-4H,6H-pyrazolo[1,5-c]thiazol-2-ylmethyl]-6-bromo-7-oxo-, (4-nitrophenyl)methyl ester, (5R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(acetyloxy)-4H,6H-pyrazolo[1,5-c]thiazol-2-ylmethyl]-6-bromo-7-oxo-, (4-nitrophenyl)methyl ester, (5R)-(623906-33-2)
• EPA Substance Registry System: 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 6-[(acetyloxy)-4H,6H-pyrazolo[1,5-c]thiazol-2-ylmethyl]-6-bromo-7-oxo-, (4-nitrophenyl)methyl ester, (5R)-(623906-33-2)

Safety Data

• Hazardous Substances Data: 623906-33-2(Hazardous Substances Data)

Upstream product

• 623564-68-1 4H-5-Thia-1,6a-diazapentalen-2-carbaldehyde 
• 108-24-7 acetic anhydride 
• 623564-16-9 (5R,6S)-6-bromo-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitrobenzyl ester 

Relevant articles and documents

Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors

This invention relates to certain bicyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present invention when combined with β-lactam antibiotics will provide an effective treatment against life threatening bacterial infections. In accordance with the present invention there are provided compounds of general formula I or a pharmaceutically acceptable salt or in vivo hydrolyzable ester R5 thereof: wherein: One of A and B denotes hydrogen and the other an optionally substituted fused bicyclic heteroaryl group; and X═O or S.

PROCESS FOR PREPARING 6-ALKYLIDENE PENEM DERIVATIVES

The present invention provides a process of making compounds of Formula (I), which are useful for the treatment of bacterial infection or disease.