623918-49-0 Usage
Description
Ethyl 5-iodo-1H-indole-2-carboxylate is a chemical compound with the molecular formula C12H10INO2. It is a derivative of indole, an aromatic heterocyclic compound, with an ethyl ester and an iodo substituent. ethyl 5-iodo-1H-indole-2-carboxylate is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various indole derivatives.
Used in Pharmaceutical Research:
Ethyl 5-iodo-1H-indole-2-carboxylate is used as a building block for the synthesis of potentially bioactive compounds and pharmaceuticals. It is utilized in the development of indole-containing molecules due to their diverse biological activities.
Used in Organic Synthesis:
Ethyl 5-iodo-1H-indole-2-carboxylate is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and functional groups make it a valuable component in the creation of new chemical entities.
The precise properties and potential uses of ethyl 5-iodo-1H-indole-2-carboxylate in various applications are subjects of ongoing scientific research, indicating its importance and versatility in the fields of chemistry and medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 623918-49-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,3,9,1 and 8 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 623918-49:
(8*6)+(7*2)+(6*3)+(5*9)+(4*1)+(3*8)+(2*4)+(1*9)=170
170 % 10 = 0
So 623918-49-0 is a valid CAS Registry Number.
623918-49-0Relevant articles and documents
Preparation of ethyl 5-iodo-1H-indole-2-carboxylate
Beshore, Douglas C.,Dinsmore, Christopher J.
, p. 2423 - 2427 (2003)
A facile, two step procedure for the preparation of ethyl 5-iodo-1H-indole-2-carboxylate (1) from commercially available ethyl 1H-indole-2-carboxylate is described herein, employing a regioselective C3, C5-bisiodination followed by zinc-mediated C3-dehalogenation.
N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl) heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists
Newman, Amy Hauck,Grundt, Peter,Cyriac, George,Deschamps, Jeffrey R.,Taylor, Michelle,Kumar, Rakesh,Ho, David,Luedtke, Robert R.
experimental part, p. 2559 - 2570 (2010/03/01)
In the present report, the D3 receptor pharmacophore is modified in the 2,3-diCl- and 2-OCH3-phenyl-piperazine class of compounds with the goal to improve D3 receptor affinity and selectivity. This extension of structure-activity relationships
TYROSINE KINASE INHIBITORS
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Page 87, (2008/06/13)
The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.
