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Ethyl 5-iodo-1H-indole-2-carboxylate is a chemical compound with the molecular formula C12H10INO2. It is a derivative of indole, an aromatic heterocyclic compound, with an ethyl ester and an iodo substituent. ethyl 5-iodo-1H-indole-2-carboxylate is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various indole derivatives.
Used in Pharmaceutical Research:
Ethyl 5-iodo-1H-indole-2-carboxylate is used as a building block for the synthesis of potentially bioactive compounds and pharmaceuticals. It is utilized in the development of indole-containing molecules due to their diverse biological activities.
Used in Organic Synthesis:
Ethyl 5-iodo-1H-indole-2-carboxylate is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and functional groups make it a valuable component in the creation of new chemical entities.
The precise properties and potential uses of ethyl 5-iodo-1H-indole-2-carboxylate in various applications are subjects of ongoing scientific research, indicating its importance and versatility in the fields of chemistry and medicine.

623918-49-0

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623918-49-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 623918-49-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,3,9,1 and 8 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 623918-49:
(8*6)+(7*2)+(6*3)+(5*9)+(4*1)+(3*8)+(2*4)+(1*9)=170
170 % 10 = 0
So 623918-49-0 is a valid CAS Registry Number.

623918-49-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 5-iodo-1H-indole-2-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:623918-49-0 SDS

623918-49-0Relevant academic research and scientific papers

Preparation of ethyl 5-iodo-1H-indole-2-carboxylate

Beshore, Douglas C.,Dinsmore, Christopher J.

, p. 2423 - 2427 (2003)

A facile, two step procedure for the preparation of ethyl 5-iodo-1H-indole-2-carboxylate (1) from commercially available ethyl 1H-indole-2-carboxylate is described herein, employing a regioselective C3, C5-bisiodination followed by zinc-mediated C3-dehalogenation.

NOVEL SUBSTITUTED INDOLE DERIVATIVES AS GAMMA SECRETASE MODULATORS

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Page/Page column 67, (2013/03/26)

The present invention is concerned with novel substituted indole derivatives of Formula (I) wherein R1, R2, R3, A1, A2, A3, Y and X have the meaning defined in the claims. The compounds according to the present invention are useful as gamma secretase modulators. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

N-(4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl) heterobiarylcarboxamides with functionalized linking chains as high affinity and enantioselective D3 receptor antagonists

Newman, Amy Hauck,Grundt, Peter,Cyriac, George,Deschamps, Jeffrey R.,Taylor, Michelle,Kumar, Rakesh,Ho, David,Luedtke, Robert R.

experimental part, p. 2559 - 2570 (2010/03/01)

In the present report, the D3 receptor pharmacophore is modified in the 2,3-diCl- and 2-OCH3-phenyl-piperazine class of compounds with the goal to improve D3 receptor affinity and selectivity. This extension of structure-activity relationships

Combination therapy

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, (2008/06/13)

The present invention relates to methods of treating cancer using a combination of at least two Akt inhibitors or a compound which is an inhibitor of Akt and an inhibitor of a protein kinase, which methods comprise administering to a mammal, either sequentially in any order or simultaneously, amounts of at least two therapeutic agents selected from a group consisting of a compound(s) which are inhibitors of Akt and compound(s) which are inhibitors of protein kinases. The invention also relates to methods of preparing such compositions.

TYROSINE KINASE INHIBITORS

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Page 87, (2008/06/13)

The present invention relates to compounds that are capable of inhibiting, modulating and/or regulating signal transduction of both receptor-type and non-receptor type tyrosine kinases. The compounds of the instant invention possess a core structure that comprises a sulfonyl indole moiety. The present invention is also related to the pharmaceutically acceptable salts, hydrates and stereoisomers of these compounds.

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