623931-49-7Relevant academic research and scientific papers
Synthesis and Transformations of 9-Substituted Imidazo[1,2-a]benzimidazole-2-carbaldehydes
Divaeva, L. N.,Kuz?menko, T. A.,Morkovnik, A. S.
, p. 1160 - 1165 (2020)
Abstract: Ethyl 2-formyl-9-methyl-9H-imidazo[1,2-a]benzimidazole-3-carboxylate was synthesized for the first time in a high yield by heating a solution of ethyl 2-(dibromomethyl)-9-methyl-9H-imidazo[1,2-a]benzimidazole-3-carboxylate in ethanol. Acid hydrolysis of the product gave less accessible 9-methylimidazobenzimidazole-2-carbaldehyde. Ethyl 2-formyl-9-methyl-9H-imidazo[1,2-a]benzimidazole-3-carboxylate underwent cyclization to fused oxopyridazine derivative by treatment with hydrazine hydrate, it reacted as a typical aldehyde with acetophenones, hydroxylamine hydrochloride, and malononitrile, and its reaction with acetylacetone and thiourea (Biginelli reaction) afforded the corresponding pyrimidine derivative.
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases
Venkatesan, Aranapakam M.,Agarwal, Atul,Abe, Takao,Ushirogochi, Hideki,Ado, Mihira,Tsuyoshi, Takasaki,Dos Santos, Osvaldo,Li, Zhong,Francisco, Gerry,Lin, Yang I.,Petersen, Peter J.,Yang, Youjun,Weiss, William J.,Shlaes, David M.,Mansour, Tarek S.
, p. 1890 - 1902 (2008/09/21)
β-Lactamases are serine- and metal-dependent hydrolases, produced by the bacteria as defense against β-lactam antibiotics. Commercially available inhibitors such as clavulanic acid, sulbactam, and tazobactam, which are currently used in the hospital setti
Tricyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors
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Page/Page column 23, (2010/11/25)
This invention relates to certain tricyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present inventio
Process for preparing 6-alkylidene penem derivatives
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, (2008/06/13)
The present invention provides a process of making compounds of formula I, which are useful for the treatment of bacterial infection or disease.
HETEROTRICYCLYL 6-ALKYLIDENE-PENEMS AS ΒΕΤΑ-LACTAMASE INHIBITORS
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Page/Page column 134-135, (2008/06/13)
The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
