623932-04-7Relevant academic research and scientific papers
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases
Venkatesan, Aranapakam M.,Agarwal, Atul,Abe, Takao,Ushirogochi, Hideki,Ado, Mihira,Tsuyoshi, Takasaki,Dos Santos, Osvaldo,Li, Zhong,Francisco, Gerry,Lin, Yang I.,Petersen, Peter J.,Yang, Youjun,Weiss, William J.,Shlaes, David M.,Mansour, Tarek S.
, p. 1890 - 1902 (2008)
β-Lactamases are serine- and metal-dependent hydrolases, produced by the bacteria as defense against β-lactam antibiotics. Commercially available inhibitors such as clavulanic acid, sulbactam, and tazobactam, which are currently used in the hospital setti
Tricyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors
-
Page/Page column 33, (2010/11/25)
This invention relates to certain tricyclic 6-alkylidene penems which act as a inhibitor of class-D enzymes. β-Lactamases hydrolyze β-lactam antibiotics, and as such serve as the primary cause of bacterial resistance. The compounds of the present inventio
Process for preparing 6-alkylidene penem derivatives
-
, (2008/06/13)
The present invention provides a process of making compounds of formula I, which are useful for the treatment of bacterial infection or disease.
HETEROTRICYCLYL 6-ALKYLIDENE-PENEMS AS ΒΕΤΑ-LACTAMASE INHIBITORS
-
Page/Page column 162, (2008/06/13)
The present invention provides a compound of formula I, pharmaceutical compositions and the use thereof for the treatment of bacterial infection or disease in a patient in need thereof.
