623950-08-3

Upstream product

• 623950-02-7 (S)-2-((tert-butoxycarbonyl)amino)-3-(4-carbamoyl-2,6-dimethylphenyl)propanoic acid 
• 422572-64-3 (S)-3-(4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydroisoquinoline 
• 958001-93-9 racemic-2-tert-butoxycarbonylamino-3-(4-carbamoyl-2,6-dimethylphenyl)propionic acid 
• 1153426-19-7 3-(4-phenyl-1H-imidazol-2-yl)-1,2,3,4-tetrahydro-isoquinoline 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF OPIOID MODULATORS

The present invention is directed to novel processes for the preparation of opioid modulators (agonists and antagonists) and intermediates in their synthesis. The opioid modulators are useful for the treatment and prevention of as pain and gastrointestina

Identification of potent phenyl imidazoles as opioid receptor agonists

Using previously reported opioid receptor (OR) agonist analogs 4a-c as starting points, the structure-activity relationship (SAR) for their related series has been further refined. This SAR study has led to the identification of 2,6-di-Me-Tyr (DMT) analog

Novel compounds as opioid receptor modulators

This invention is directed towards novel compounds as opioid receptor modulators, antagonists, and agonists useful for the treatment of opioid modulated disorders such as pain and gastrointestinal disorders.