624-40-8 Usage
General Description
1,2,4,5-tetrazinane-3,6-dione, also known as Temozolomide, is a chemical compound that is commonly used as a medication for the treatment of certain types of brain cancer, including glioblastoma multiforme. It works by altering the DNA in cancer cells, leading to their death. Temozolomide is an antimetabolite, meaning it interferes with the growth of cancer cells by mimicking the structure of normal chemicals in the cell. It is typically administered orally in the form of capsules and is well-absorbed into the bloodstream. Common side effects of Temozolomide include nausea, vomiting, and low blood cell counts, and it may also increase the risk of developing certain types of leukemia. Despite these side effects, Temozolomide is an important and widely used medication in the treatment of brain cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 624-40-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,2 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 624-40:
(5*6)+(4*2)+(3*4)+(2*4)+(1*0)=58
58 % 10 = 8
So 624-40-8 is a valid CAS Registry Number.
624-40-8Relevant articles and documents
Reaction of anhydrous zinc chloride with 2,3-thiophenedicarbaldehyde bis(semicarbazone) (2,3BSTCH2) and bis(thiosemicarbazone) (2,3BTSTCH2): Crystal structure of {[C6H5N2S]+[ZnCl3(C6H4N2S)]-} complex
Alomar, Kusa?,Allain, Magali,Richomme, Pascal,Bouet, Gilles
, p. 1591 - 1597 (2015/10/20)
The reaction of anhydrous zinc chloride with 2,3-thiophenedicarbaldehyde bis(semicarbazone) or 2,3-bis(thiosemicarbazone) leads to the formation of compound {[C6H5N2S]+[ZnCl3(C6H4N2S)]-}, where C6H4N2S is thieno[2,3-d]pyridazine, via an elimination-cyclisation reaction of the semicarbazone or the thiosemicarbazone moiety. Crystal structures of thieno[2,3-d]pyridazine and {[C6H5N2S]+[ZnCl3(C6H4N2S)]-} are described. 2015 Institute of Chemistry, Slovak Academy of Sciences
1,2,4,5-Tetrahydro-1,2,4,5-tetrazin-2,6-dione (p-Urazine) and Its Conversion into 1,2,4,5-Tetrazine Derivatives
Neugebauer, Franz Alfred,Fischer, Hans
, p. 387 - 395 (2007/10/02)
Cyclization of 4 with phosgene and subsequent hydrogenolysis of the protecting benzyl groups yielded the yet unknown p-urazine (1) which rearranges thermally to the tetrazolidine 2.Compound 1 was dehydrogenated to give 14 which exists in solution in the t
