62423-73-8

Basic information

• Product Name: 3-(2-BROMOACETYL)BENZOIC ACID
• Synonyms: 3-(2-BROMOACETYL)BENZOIC ACID;RARECHEM AL BO 0926;3-(BroMoactyl)benzoic acid;3-Carboxyphenacyl bromide, 2-Bromo-1-(3-carboxyphenyl)ethanone;3-Carboxyphenacyl bromide, 2-Bromo-1-(3-carboxyphenyl)ethan-1-one
• CAS NO: 62423-73-8
• Molecular Formula: C₉H₇BrO₃
• Molecular Weight: 243.05
• Mol File: 62423-73-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 147-149°C
• Boiling Point: 388.9±22.0 °C(Predicted)
• Appearance: /
• Density: 1.657±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.74±0.10(Predicted)
• CAS DataBase Reference: 3-(2-BROMOACETYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-BROMOACETYL)BENZOIC ACID(62423-73-8)
• EPA Substance Registry System: 3-(2-BROMOACETYL)BENZOIC ACID(62423-73-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Hazardous Substances Data: 62423-73-8(Hazardous Substances Data)

Usage

General Description

3-(2-Bromoacetyl)benzoic acid, also known as o-Bromoacetylbenzoic acid, is a chemical compound with the molecular formula C9H7BrO3. It is a derivative of benzoic acid with an acetyl group attached to the second carbon and a bromine atom attached to the third carbon of the benzene ring. This chemical is commonly used in organic synthesis and as an intermediate in the production of pharmaceuticals and agrochemicals. It is a white to off-white crystalline powder that is sparingly soluble in water but soluble in organic solvents such as ethanol and methanol. Its chemical properties make it suitable for a variety of applications in the chemical and pharmaceutical industries.

Upstream product

• 586-42-5 3-acetylbenzoic acid 

Downstream Products

• 27475-19-0 α-bromo-3-acetylbenzoic acid methyl ester 
• 722516-93-0 2-{[2-(3-carboxyphenyl)-2-oxoethyl]thio}benzoic acid 
• 860344-60-1 3-[2-(4-methyl-piperazin-1-yl)-thiazol-4-yl]-benzoic acid 
• 860344-61-2 3-(2-isopropylamino-thiazol-4-yl)-benzoic acid 
• 579476-31-6 3-oxoacetyl-benzoic acid 
• 473548-36-6 3-(2-bromo-1,1-dimethoxy-ethyl)-benzoic acid methyl ester 
• 473548-57-1 3-thiazol-4-yl-benzoic acid methyl ester 
• 473548-38-8 3-(2-methyl-oxazol-4-yl)-benzoic acid 
• 473548-78-6 3-dihydroxyacetyl-benzoic acid methyl ester 
• 28077-40-9 Diethylammonium 3-(2-methyl thiazol-4-yl) benzoate 

Relevant articles and documents

Discovery and structure-activity relationship of the first non-pep tide competitive human glucagon receptor antagonists

The first non-peptide competitive human glucagon receptor antagonist, 2-(benzimidazol-2ylthio)-l-(3,4-dihydroxyphenyl)-l-ethanone, NNC 92-1687 (2), is described. This antagonist has a binding affinity of 20 μM (ICso) and a functional Ki = 9.1 μM at the human glucagon receptor. A structure-activity relationship (SAR) was obtained on this compound, and the results show that only the benzimidazole part can be changed without complete loss of affinity. Analogues with tert-butyl or benzyloxy groups in the 5-position of the benzimidazole moiety were found to be equipotent or slightly more potent, all displaying binding affinities around 5-20 μM. Most of the changes to the catechol and the linker gave compounds without any affinity toward the human glucagon receptor. The 3-hydroxy group could, however, in the presence of a 4-hydroxy group be changed to a methoxy or a chloro group while retaining affinity.

Novel thiazole derivatives as inhibitors of superoxide production by human neutrophils: Synthesis and structure-activity relationships

Neutrophils have an important role in the self-defense systems of organisms through the production of superoxide. On the other hand, it has been proposed that abnormal amounts of superoxide produced by neutrophils are a serious factor in tissue injury. A series of novel thiazole derivatives was prepared and evaluated inhibitory effect on superoxide production by human neutrophils in vitro. Among these compounds, 6-[2-(3,4- diethoxyphenyl)thiazol-4-yl]-pyridine-2-carboxylic acid (OPC-6535) was selected as one of the most promising compounds. The synthesis and structure- activity relationships of these compounds are reported herein.