62442-59-5Relevant articles and documents
Synthetic studies towards the development of psoralen-acidic retinoid conjugates and hybrids
Militsopoulou, Maria,Bariamis, Stavros E.,Athanassopoulos, Constantinos M.,Papaioannou, Dionissios
experimental part, p. 3433 - 3442 (2009/05/26)
The chemical modification of trioxsalen using electrophilic aromatic substitution reactions, followed by either Wittig or Heck reactions or Suzuki coupling, allowed for ready access to C4′ modified trioxsalen derivatives that were successfully used for th
Psoralens
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, (2008/06/13)
New psoralen compounds have been synthesized. The compounds all include the addition of substituent groups at the 4' position on the basic trioxsalen structure. Specifically, the compounds have the structure: STR1 wherein X may be any desired substituent such as halogenated alkyls, alcohols, ethers, aminoalkyls, etc. The new substituted psoralens exhibit high solubility in aqueous solution and low dissociation constants from deoxyribonucleic acid (DNA), as well as a reactivity with ribonucleic acids (RNA). Such psoralen compounds find use in the study of secondary structures of nucleic acids; as inhibitors of RNA replication; in the inactivation of viruses; and in the photo chemotherapy of psoriasis.
