62452-00-0Relevant academic research and scientific papers
Synthesis and skeletal muscle relaxant activity of 3-(aminoacyl)-1-[[[5-(substituted phenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinediones
Wessels,Ellis,White Jr.
, p. 1088 - 1090 (1981)
A series of 3-(aminoacyl)-1-[[[5-(substituted phenyl)-2-furanyl]methylene]amino]-2,4-imidazolidinediones was synthesized and evaluated for skeletal muscle relaxant activity. All compounds were active by the intravenous route, and nine of 11 were active orally. One compound was very active when evaluated by the mouse Straub tail and rotarod tests; its efficacy index (ED50 rotarod/ED50Straub tail) was 2.0, while its therapeutic index (LD50/ED50Straub tail) was >225.
3-(Aminoacyl)-1-{[5-(substituted phenyl)furfurylidene]amino}hydantoins and process for their preparation thereof
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, (2008/06/13)
A series of 3-(aminoacyl)-1-{[5-(substituted phenyl)furfurylidene] amino}hydantoins are useful as muscle relaxants. A process for their preparation is also described.
