62452-64-6

Upstream product

• 26037-61-6 2-bromo-3-methoxy-1,4-naphthoquinone 
• 766-97-2 4-n-methylphenylacetylene 
• 83-72-7 2-hydroxynaphtho-1,4-quinone 
• 33491-05-3 1-(2-bromoethynyl)-4-methylbenzene 

Relevant academic research and scientific papers

Transition-Metal-Free One-Pot Synthesis of Naphthoquinonefuran Derivatives through Sequential Nucleophilic Substitution-Nucleophilic Addition Reaction

A transition-metal-free route for tandem one-pot synthesis of naphthoquinonefuran derivatives from 2-hydroxynaphthoquinones has been developed. The sequentially accomplished process comprises an intermolecular alkynylation of sp2-carbon at the 3 position of 2-hydroxynaphthoquinones with arylethynyl bromides, followed by a base-promoted intramolecular nucleophilic annulation reaction. A broad range of functional groups is compatible with this reaction, and diverse naphtho[2,3-b]furan-4,9-diones can be obtained with good yields and excellent regioselectivity.

Method for synthesizing coumarone naphthoquinone derivative

The invention discloses a method for synthesizing a coumarone naphthoquinone derivative. The method comprises the following steps that 2-hydroxyl-3-substituted ethylene-1,4-naphthoquinone is used as raw materials, and the angular coumarone naphthoquinone derivative is synthesized in an organic solvent under the effect of iodine; or the 2-hydroxyl-3-substituted ethylene-1,4-naphthoquinone is used as raw materials, the angular coumarone naphthoquinone derivative is firstly synthesized in an organic solvent under the effect of the iodine, and then, the angular coumarone naphthoquinone derivative is used for synthesizing the straight coumarone naphthoquinone derivative under the acid condition. The method has the advantages that the experiment steps are few; the operation is simple; the selectivity is high; the yield is high; a higher application value is realized.

The iodine-mediated highly regioselective synthesis of angular and linear naphthofuroquinones

Naphthofuroquinones are of great value in medicinal chemistry. In this letter, a facile method for highly regioselective synthesis of both linear and angular naphthofuroquinones has been developed via iodine mediated cyclization of 2-hydroxy-3-substituted