62459-43-2

Upstream product

• 16458-77-8 3-phenylthiazolo<3,2-a>benzimidazole 
• 74-88-4 methyl iodide 
• 95-54-5 1,2-diamino-benzene 
• 583-39-1 2,3-dihydrobenzimidazol-2-thione 
• 28100-28-9 1,3-dihydro-benzoimidazole-2-thione; mercury(II) salt (2:1) 
• 6077-10-7 bis(phenylethynyl)mercury 

Relevant academic research and scientific papers

Access to N-thioalkenyl and N-(o-thio)aryl-benzimidazol-2-ones by ring opening of thiazolobenzimidazolium and benzimidazobenzothiazolium salts and C-O bond cleavage of an alkoxide

We report herein the synthesis of highly functionalized 1,3-dihydro-2H-benzimidazol-2-ones via a ring opening of thiazolo[3,2-a]benzimidazolium or benzimidazo[2,1-b][1,3]benzothiazol-6-ium salts and an unusual C-O bond cleavage of an alkoxide. A large variety of benzimidazolones bearing an original N-thioalkenyl or N-(o-thio)aryl group was obtained in high yields. The developed chemistry provides efficient and rapid access to the privileged benzimidazol-2-one scaffold.