62472-27-9Relevant academic research and scientific papers
Copper(II)-catalyzed aerobic oxidative coupling between chalcone and 2-aminopyridine via C-H amination: An expedient synthesis of 3-aroylimidazo[1,2-a]pyridines
Monir, Kamarul,Kumar Bagdi, Avik,Mishra, Subhajit,Majee, Adinath,Hajra, Alakananda
, p. 1105 - 1112 (2014)
A simple and efficient protocol has been developed for the synthesis of 3-aroylimidazopyridines via copper(II) acetate-catalyzed aerobic oxidative amination. A library of 3-aroylimidazopyridines was synthesized from readily accessible chalcones and 2-aminopyridines with high yields and regioselectivity. The reaction proceeds through a tandem Michael addition followed by an intramolecular oxidative amination. The successful application of this methodology for a gram-scale reaction indicates its potential for bulk synthesis.
