624732-11-2

Upstream product

• 624732-32-7 (1R,2R)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol 
• 74-88-4 methyl iodide 
• 624732-06-5 (1R,2S)-2-(methyl-{[(1R,2R)-2-phenylcyclopropyl](methyl)}amino)-1-phenylpropan-1-ol 
• 902757-59-9 (S)-1,1,1-Trifluoro-3-[methyl-((E)-3-phenyl-allyl)-amino]-propan-2-ol 
• 902757-57-7 (S)-1,1,1-Trifluoro-3-[methyl-((1R,2R)-2-phenyl-cyclopropylmethyl)-amino]-propan-2-ol 
• 60960-88-5 (E)-N-methylcinnamylamine 
• 90-86-8 (1R,2S)-2-{methyl-[(E)-3-phenyl-2-propenyl]amino}-1-phenylpropan-1-ol 
• 4392-24-9 Cinnamyl bromide 
• 624732-04-3 (1R,2R)-2-{methyl-[(E)-3-phenyl-2-propenyl]amino}-1-phenylpropan-1-ol 

Relevant academic research and scientific papers

Trifluoromethylated amino alcohol as chiral auxiliary for highly diastereoselective and fast Simmons-Smith cyclopropanation of allylic amine

Three advantages of a trifluoromethylated amino alcohol auxiliary in the Simmons-Smith cyclopropanation of allylic amines are described. The trifluoromethylated amino alcohol auxiliary reduces unwanted side reactions induced by its acidic, and thus less n

Highly Diastereoselective Simmons-Smith Cyclopropanation of Allylic Amines

(Equation presented) Cyclopropanation of allylic tertiary amines using the Simmons-Smith reagent has been achieved by employing chelating groups in close proximity to the amine. The chelating groups promote cyclopropanation at the expense of N-ylide formation. Using pseudoephedrine as the chelating group, high diastereoselectivity is observed.